![](/images/graphics-bg.png)
Gender Differences of B Cell Signature in Healthy Subjects Underlie Disparities in Incidence and Course of SLE Related to Estrogen
المؤلفون المشاركون
Fan, Hongye
Dong, Guanjun
Zhao, Guangfeng
Liu, Fei
Yao, Genghong
Zhu, Yichao
Hou, Yayi
المصدر
Journal of Immunology Research
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-13
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
The aim of the present study was to investigate mechanism of the gender differences of B cells.
The results showed that 358 differential gene expressions (DEGs) were displayed between healthy females and males.
Compared with male, 226 and 132 genes were found to be up- and downregulated in the female.
116 genes displayed possible correlation with estrogen.
Moreover, the upregulated DEGs (Cav1, CD200R1, TNFRSF17, and CXCR3) and downregulated DEGs (EIF1AY and DDX3Y) in healthy female may be involved in gender predominance of some immune diseases.
Furthermore, signaling pathway analysis for estrogen-relevant DEGs showed that only 26 genes were downregulated in SLE female versus SLE male, of which expressions of 8 genes had significant difference between SLE females and SLE males but are having nonsignificant difference between healthy females and healthy males.
Except for the 5 Y-chromosome-related genes or varients, only 3 DEGs (LTF, CAMP, and DEFA4) were selected and qRT-PCR confirmed that the expressions of LTF and CAMP decreased significantly in B cells from female SLE patients.
These data indicated that the gender differences were existent in global gene expression of B cells and the difference may be related to estrogen.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fan, Hongye& Dong, Guanjun& Zhao, Guangfeng& Liu, Fei& Yao, Genghong& Zhu, Yichao…[et al.]. 2014. Gender Differences of B Cell Signature in Healthy Subjects Underlie Disparities in Incidence and Course of SLE Related to Estrogen. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1040990
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fan, Hongye…[et al.]. Gender Differences of B Cell Signature in Healthy Subjects Underlie Disparities in Incidence and Course of SLE Related to Estrogen. Journal of Immunology Research No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-1040990
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fan, Hongye& Dong, Guanjun& Zhao, Guangfeng& Liu, Fei& Yao, Genghong& Zhu, Yichao…[et al.]. Gender Differences of B Cell Signature in Healthy Subjects Underlie Disparities in Incidence and Course of SLE Related to Estrogen. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1040990
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040990
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)