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Gender Differences of B Cell Signature in Healthy Subjects Underlie Disparities in Incidence and Course of SLE Related to Estrogen
Joint Authors
Fan, Hongye
Dong, Guanjun
Zhao, Guangfeng
Liu, Fei
Yao, Genghong
Zhu, Yichao
Hou, Yayi
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-13
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The aim of the present study was to investigate mechanism of the gender differences of B cells.
The results showed that 358 differential gene expressions (DEGs) were displayed between healthy females and males.
Compared with male, 226 and 132 genes were found to be up- and downregulated in the female.
116 genes displayed possible correlation with estrogen.
Moreover, the upregulated DEGs (Cav1, CD200R1, TNFRSF17, and CXCR3) and downregulated DEGs (EIF1AY and DDX3Y) in healthy female may be involved in gender predominance of some immune diseases.
Furthermore, signaling pathway analysis for estrogen-relevant DEGs showed that only 26 genes were downregulated in SLE female versus SLE male, of which expressions of 8 genes had significant difference between SLE females and SLE males but are having nonsignificant difference between healthy females and healthy males.
Except for the 5 Y-chromosome-related genes or varients, only 3 DEGs (LTF, CAMP, and DEFA4) were selected and qRT-PCR confirmed that the expressions of LTF and CAMP decreased significantly in B cells from female SLE patients.
These data indicated that the gender differences were existent in global gene expression of B cells and the difference may be related to estrogen.
American Psychological Association (APA)
Fan, Hongye& Dong, Guanjun& Zhao, Guangfeng& Liu, Fei& Yao, Genghong& Zhu, Yichao…[et al.]. 2014. Gender Differences of B Cell Signature in Healthy Subjects Underlie Disparities in Incidence and Course of SLE Related to Estrogen. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1040990
Modern Language Association (MLA)
Fan, Hongye…[et al.]. Gender Differences of B Cell Signature in Healthy Subjects Underlie Disparities in Incidence and Course of SLE Related to Estrogen. Journal of Immunology Research No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-1040990
American Medical Association (AMA)
Fan, Hongye& Dong, Guanjun& Zhao, Guangfeng& Liu, Fei& Yao, Genghong& Zhu, Yichao…[et al.]. Gender Differences of B Cell Signature in Healthy Subjects Underlie Disparities in Incidence and Course of SLE Related to Estrogen. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1040990
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040990