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Oxidative Stress Is Differentially Present in Multiple Sclerosis Courses, Early Evident, and Unrelated to Treatment
المؤلفون المشاركون
Rovaris, Marco
Clerici, Mario
Borgiani, Bruno
Mariani, Enrica
Cursano, Cristina
Mendozzi, Laura
Cavarretta, Rossella
Comi, Giancarlo
Furlan, Roberto
Gironi, M.
Saresella, Marina
المصدر
Journal of Immunology Research
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-26
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Oxidative stress is well documented in multiple sclerosis (MS) lesions, but its correspondence at peripheral level is still controversial.
Objective.
To evaluate peripheral oxidative stress markers in MS patients.
Methods.
We studied total blood levels of Coenzyme Q10 (CoQ10), oxidized and reduced forms of glutathione, malondialdehyde, reactive oxygen species (ROS), anti-oxidized-low-density lipoproteins (anti-oxLDL) antibodies, and antioxidant power (PAO) in 87 patients with different MS clinical phenotypes and in 77 controls.
Results.
CoQ10 was lower whereas anti-oxLDL antibodies titer was higher in MS patients than in controls.
The benign variant of MS displayed both higher CoQ10 and higher anti-oxLDL than other MS clinical variants.
Female patients had lower CoQ10 and PAO and higher ROS than male patients.
Differences were greater in younger patients with shorter disease duration.
Surprisingly, there was no difference for these markers between treated and untreated patients.
Conclusion.
We found lower antioxidant agents and higher anti-oxLDL antibodies in MS, and the highest antibody titers occurred in the benign form.
We suggest that natural anti-oxLDL antibodies can be protective against MS, saving blood brain barrier integrity.
Our findings also suggest that milder MS is associated with a distinct oxidative stress pattern, which may provide a useful biomarker of disease prognosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gironi, M.& Borgiani, Bruno& Mariani, Enrica& Cursano, Cristina& Mendozzi, Laura& Cavarretta, Rossella…[et al.]. 2014. Oxidative Stress Is Differentially Present in Multiple Sclerosis Courses, Early Evident, and Unrelated to Treatment. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1041022
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gironi, M.…[et al.]. Oxidative Stress Is Differentially Present in Multiple Sclerosis Courses, Early Evident, and Unrelated to Treatment. Journal of Immunology Research No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1041022
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gironi, M.& Borgiani, Bruno& Mariani, Enrica& Cursano, Cristina& Mendozzi, Laura& Cavarretta, Rossella…[et al.]. Oxidative Stress Is Differentially Present in Multiple Sclerosis Courses, Early Evident, and Unrelated to Treatment. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1041022
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1041022
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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