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Oxidative Stress Is Differentially Present in Multiple Sclerosis Courses, Early Evident, and Unrelated to Treatment
Joint Authors
Rovaris, Marco
Clerici, Mario
Borgiani, Bruno
Mariani, Enrica
Cursano, Cristina
Mendozzi, Laura
Cavarretta, Rossella
Comi, Giancarlo
Furlan, Roberto
Gironi, M.
Saresella, Marina
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Oxidative stress is well documented in multiple sclerosis (MS) lesions, but its correspondence at peripheral level is still controversial.
Objective.
To evaluate peripheral oxidative stress markers in MS patients.
Methods.
We studied total blood levels of Coenzyme Q10 (CoQ10), oxidized and reduced forms of glutathione, malondialdehyde, reactive oxygen species (ROS), anti-oxidized-low-density lipoproteins (anti-oxLDL) antibodies, and antioxidant power (PAO) in 87 patients with different MS clinical phenotypes and in 77 controls.
Results.
CoQ10 was lower whereas anti-oxLDL antibodies titer was higher in MS patients than in controls.
The benign variant of MS displayed both higher CoQ10 and higher anti-oxLDL than other MS clinical variants.
Female patients had lower CoQ10 and PAO and higher ROS than male patients.
Differences were greater in younger patients with shorter disease duration.
Surprisingly, there was no difference for these markers between treated and untreated patients.
Conclusion.
We found lower antioxidant agents and higher anti-oxLDL antibodies in MS, and the highest antibody titers occurred in the benign form.
We suggest that natural anti-oxLDL antibodies can be protective against MS, saving blood brain barrier integrity.
Our findings also suggest that milder MS is associated with a distinct oxidative stress pattern, which may provide a useful biomarker of disease prognosis.
American Psychological Association (APA)
Gironi, M.& Borgiani, Bruno& Mariani, Enrica& Cursano, Cristina& Mendozzi, Laura& Cavarretta, Rossella…[et al.]. 2014. Oxidative Stress Is Differentially Present in Multiple Sclerosis Courses, Early Evident, and Unrelated to Treatment. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1041022
Modern Language Association (MLA)
Gironi, M.…[et al.]. Oxidative Stress Is Differentially Present in Multiple Sclerosis Courses, Early Evident, and Unrelated to Treatment. Journal of Immunology Research No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1041022
American Medical Association (AMA)
Gironi, M.& Borgiani, Bruno& Mariani, Enrica& Cursano, Cristina& Mendozzi, Laura& Cavarretta, Rossella…[et al.]. Oxidative Stress Is Differentially Present in Multiple Sclerosis Courses, Early Evident, and Unrelated to Treatment. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1041022
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1041022