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Comparison of Low-Dose Rosuvastatin with Atorvastatin in Lipid-Lowering Efficacy and Safety in a High-Risk Pakistani Cohort: An Open-Label Randomized Trial
المؤلف
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-30
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Treatment of hyperlipidemia is helpful in both primary and secondary prevention of coronary heart disease and stroke.
Aim.
To compare lipid-lowering efficacy of rosuvastatin with atorvastatin.
Methodology.
This open-label randomized controlled trial was carried out at 1 Mountain Medical Battalion from September 2012 to August 2013 on patients with type 2 diabetes, hypertension, myocardial infarction, or stroke, meriting treatment with a statin.
Those with secondary causes of dyslipidemia were excluded.
Blood samples for estimation of serum total cholesterol, triglycerides, HDL-C, and LDL-C were collected after a 12-hour fast.
Patients were randomly allocated to receive either atorvastatin 10 mg HS or rosuvastatin 5 mg HS daily.
Lipid levels were rechecked after six weeks.
Results.
Atorvastatin was used in 63 patients and rosuvastatin in 66.
There was a greater absolute and percent reduction in serum LDL-C levels with rosuvastatin as compared to atorvastatin (0.96 versus 0.54 mg/dL; P = 0.011 and 24.34 versus 13.66%; P = 0.045 ), whereas reduction in all other fractions was equal.
Myalgias were seen in 5 (7.94%) patients treated with atorvastatin and 8 (12.12%) patients treated with rosuvastatin (P: 0.432).
Conclusion.
Rosuvastatin produces a greater reduction in serum LDL-C levels and should therefore be preferred over atorvastatin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Arshad, Abdul Rehman. 2014. Comparison of Low-Dose Rosuvastatin with Atorvastatin in Lipid-Lowering Efficacy and Safety in a High-Risk Pakistani Cohort: An Open-Label Randomized Trial. Journal of Lipids،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1041059
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Arshad, Abdul Rehman. Comparison of Low-Dose Rosuvastatin with Atorvastatin in Lipid-Lowering Efficacy and Safety in a High-Risk Pakistani Cohort: An Open-Label Randomized Trial. Journal of Lipids No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1041059
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Arshad, Abdul Rehman. Comparison of Low-Dose Rosuvastatin with Atorvastatin in Lipid-Lowering Efficacy and Safety in a High-Risk Pakistani Cohort: An Open-Label Randomized Trial. Journal of Lipids. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1041059
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1041059
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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