Comparison of Low-Dose Rosuvastatin with Atorvastatin in Lipid-Lowering Efficacy and Safety in a High-Risk Pakistani Cohort: An Open-Label Randomized Trial
Author
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Treatment of hyperlipidemia is helpful in both primary and secondary prevention of coronary heart disease and stroke.
Aim.
To compare lipid-lowering efficacy of rosuvastatin with atorvastatin.
Methodology.
This open-label randomized controlled trial was carried out at 1 Mountain Medical Battalion from September 2012 to August 2013 on patients with type 2 diabetes, hypertension, myocardial infarction, or stroke, meriting treatment with a statin.
Those with secondary causes of dyslipidemia were excluded.
Blood samples for estimation of serum total cholesterol, triglycerides, HDL-C, and LDL-C were collected after a 12-hour fast.
Patients were randomly allocated to receive either atorvastatin 10 mg HS or rosuvastatin 5 mg HS daily.
Lipid levels were rechecked after six weeks.
Results.
Atorvastatin was used in 63 patients and rosuvastatin in 66.
There was a greater absolute and percent reduction in serum LDL-C levels with rosuvastatin as compared to atorvastatin (0.96 versus 0.54 mg/dL; P = 0.011 and 24.34 versus 13.66%; P = 0.045 ), whereas reduction in all other fractions was equal.
Myalgias were seen in 5 (7.94%) patients treated with atorvastatin and 8 (12.12%) patients treated with rosuvastatin (P: 0.432).
Conclusion.
Rosuvastatin produces a greater reduction in serum LDL-C levels and should therefore be preferred over atorvastatin.
American Psychological Association (APA)
Arshad, Abdul Rehman. 2014. Comparison of Low-Dose Rosuvastatin with Atorvastatin in Lipid-Lowering Efficacy and Safety in a High-Risk Pakistani Cohort: An Open-Label Randomized Trial. Journal of Lipids،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1041059
Modern Language Association (MLA)
Arshad, Abdul Rehman. Comparison of Low-Dose Rosuvastatin with Atorvastatin in Lipid-Lowering Efficacy and Safety in a High-Risk Pakistani Cohort: An Open-Label Randomized Trial. Journal of Lipids No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1041059
American Medical Association (AMA)
Arshad, Abdul Rehman. Comparison of Low-Dose Rosuvastatin with Atorvastatin in Lipid-Lowering Efficacy and Safety in a High-Risk Pakistani Cohort: An Open-Label Randomized Trial. Journal of Lipids. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1041059
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1041059