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Preparation and Characterization of a Collagen-Liposome-Chondroitin Sulfate Matrix with Potential Application for Inflammatory Disorders Treatment
المؤلفون المشاركون
Craciunescu, Oana
Gaspar, Alexandra
Trif, Mihaela
Moisei, Magdalena
Oancea, Anca
Moldovan, Lucia
Zarnescu, Otilia
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-15
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Smart drug delivery systems with controllable properties play an important role in targeted therapy and tissue regeneration.
The aim of our study was the preparation and in vitro evaluation of a collagen (Col) matrix embedding a liposomal formulation of chondroitin sulfate (L-CS) for the treatment of inflammatory disorders.
Structural studies using Oil Red O specific staining for lipids and scanning electron microscopy showed an alveolar network of nanosized Col fibrils decorated with deposits of L-CS at both periphery and inner of the matrix.
The porosity and density of Col-L-CS matrix were similar to those of Col matrix, while its mean pore size and biodegradability had significantly higher and lower values ( P < 0.05 ), respectively.
In vitro cytotoxicity assays showed that the matrix system induced high cell viability and stimulated cell metabolism in L929 fibroblast cell culture.
Light and electron micrographs of the cell-matrix construct showed that cells clustered into the porous structure at 72 h of cultivation.
In vitro diffusion test indicated that the quantity of released CS was significantly lower ( P < 0.05 ) after embedment of L-CS within Col matrix.
All these results indicated that the biocompatible and biodegradable Col-L-CS matrix might be a promising delivery system for local treatment of inflamed site.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Craciunescu, Oana& Gaspar, Alexandra& Trif, Mihaela& Moisei, Magdalena& Oancea, Anca& Moldovan, Lucia…[et al.]. 2014. Preparation and Characterization of a Collagen-Liposome-Chondroitin Sulfate Matrix with Potential Application for Inflammatory Disorders Treatment. Journal of Nanomaterials،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1042021
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Craciunescu, Oana…[et al.]. Preparation and Characterization of a Collagen-Liposome-Chondroitin Sulfate Matrix with Potential Application for Inflammatory Disorders Treatment. Journal of Nanomaterials No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1042021
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Craciunescu, Oana& Gaspar, Alexandra& Trif, Mihaela& Moisei, Magdalena& Oancea, Anca& Moldovan, Lucia…[et al.]. Preparation and Characterization of a Collagen-Liposome-Chondroitin Sulfate Matrix with Potential Application for Inflammatory Disorders Treatment. Journal of Nanomaterials. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1042021
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1042021
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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