Preparation and Characterization of a Collagen-Liposome-Chondroitin Sulfate Matrix with Potential Application for Inflammatory Disorders Treatment
Joint Authors
Craciunescu, Oana
Gaspar, Alexandra
Trif, Mihaela
Moisei, Magdalena
Oancea, Anca
Moldovan, Lucia
Zarnescu, Otilia
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Smart drug delivery systems with controllable properties play an important role in targeted therapy and tissue regeneration.
The aim of our study was the preparation and in vitro evaluation of a collagen (Col) matrix embedding a liposomal formulation of chondroitin sulfate (L-CS) for the treatment of inflammatory disorders.
Structural studies using Oil Red O specific staining for lipids and scanning electron microscopy showed an alveolar network of nanosized Col fibrils decorated with deposits of L-CS at both periphery and inner of the matrix.
The porosity and density of Col-L-CS matrix were similar to those of Col matrix, while its mean pore size and biodegradability had significantly higher and lower values ( P < 0.05 ), respectively.
In vitro cytotoxicity assays showed that the matrix system induced high cell viability and stimulated cell metabolism in L929 fibroblast cell culture.
Light and electron micrographs of the cell-matrix construct showed that cells clustered into the porous structure at 72 h of cultivation.
In vitro diffusion test indicated that the quantity of released CS was significantly lower ( P < 0.05 ) after embedment of L-CS within Col matrix.
All these results indicated that the biocompatible and biodegradable Col-L-CS matrix might be a promising delivery system for local treatment of inflamed site.
American Psychological Association (APA)
Craciunescu, Oana& Gaspar, Alexandra& Trif, Mihaela& Moisei, Magdalena& Oancea, Anca& Moldovan, Lucia…[et al.]. 2014. Preparation and Characterization of a Collagen-Liposome-Chondroitin Sulfate Matrix with Potential Application for Inflammatory Disorders Treatment. Journal of Nanomaterials،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1042021
Modern Language Association (MLA)
Craciunescu, Oana…[et al.]. Preparation and Characterization of a Collagen-Liposome-Chondroitin Sulfate Matrix with Potential Application for Inflammatory Disorders Treatment. Journal of Nanomaterials No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1042021
American Medical Association (AMA)
Craciunescu, Oana& Gaspar, Alexandra& Trif, Mihaela& Moisei, Magdalena& Oancea, Anca& Moldovan, Lucia…[et al.]. Preparation and Characterization of a Collagen-Liposome-Chondroitin Sulfate Matrix with Potential Application for Inflammatory Disorders Treatment. Journal of Nanomaterials. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1042021
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042021