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Organic Nanovesicular Cargoes for Sustained Drug Delivery: Synthesis, Vesicle Formation, Controlling “Pearling” States, and Terfenadine LoadingRelease Studies
المؤلفون المشاركون
Dulla, Balakrishna
Reddy, E. Ramanjaneya
Chennubhotla, Keerthana S.
Kulkarni, Pushkar
Rajadurai, Marina S.
Chandrasekar, Rajadurai
Botcha, Ajay Kumar
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-12
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
“Sustained drug delivery systems” which are designed to accomplish long-lasting therapeutic effect are one of the challenging topics in the area of nanomedicine.
We developed an innovative strategy to prepare nontoxic and polymer stabilized organic nanovesicles (diameter: 200 nm) from a novel bolaamphiphile, where two hydrogen bonding acetyl cytosine molecules connected to 4,4′′-positions of the 2,6-bispyrazolylpyridine through two flexible octyne chains.
The nanovesicles behave like biological membrane by spontaneously self-assembling into “pearl-like” chains and subsequently forming long nanotubes (diameter: 150 nm), which further develop into various types of network-junctions through self-organization.
For drug loading and delivery applications, the nanovesicles were externally protected with biocompatible poly(ethyleneglycol)-2000 to prevent them from fusion and ensuing tube formation.
Nontoxic nature of the nanovesicles was demonstrated by zebrafish teratogenicity assay.
Biocompatible nanovesicles were loaded with “terfenadine” drug and successfully utilized to transport and release drug in sustained manner (up to 72 h) in zebrafish larvae, which is recognized as an emerging in vivo model system.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Botcha, Ajay Kumar& Dulla, Balakrishna& Reddy, E. Ramanjaneya& Chennubhotla, Keerthana S.& Kulkarni, Pushkar& Chandrasekar, Rajadurai…[et al.]. 2014. Organic Nanovesicular Cargoes for Sustained Drug Delivery: Synthesis, Vesicle Formation, Controlling “Pearling” States, and Terfenadine LoadingRelease Studies. Journal of Nanotechnology،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1042198
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Botcha, Ajay Kumar…[et al.]. Organic Nanovesicular Cargoes for Sustained Drug Delivery: Synthesis, Vesicle Formation, Controlling “Pearling” States, and Terfenadine LoadingRelease Studies. Journal of Nanotechnology No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1042198
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Botcha, Ajay Kumar& Dulla, Balakrishna& Reddy, E. Ramanjaneya& Chennubhotla, Keerthana S.& Kulkarni, Pushkar& Chandrasekar, Rajadurai…[et al.]. Organic Nanovesicular Cargoes for Sustained Drug Delivery: Synthesis, Vesicle Formation, Controlling “Pearling” States, and Terfenadine LoadingRelease Studies. Journal of Nanotechnology. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1042198
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1042198
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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