Organic Nanovesicular Cargoes for Sustained Drug Delivery: Synthesis, Vesicle Formation, Controlling “Pearling” States, and Terfenadine LoadingRelease Studies
Joint Authors
Dulla, Balakrishna
Reddy, E. Ramanjaneya
Chennubhotla, Keerthana S.
Kulkarni, Pushkar
Rajadurai, Marina S.
Chandrasekar, Rajadurai
Botcha, Ajay Kumar
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
“Sustained drug delivery systems” which are designed to accomplish long-lasting therapeutic effect are one of the challenging topics in the area of nanomedicine.
We developed an innovative strategy to prepare nontoxic and polymer stabilized organic nanovesicles (diameter: 200 nm) from a novel bolaamphiphile, where two hydrogen bonding acetyl cytosine molecules connected to 4,4′′-positions of the 2,6-bispyrazolylpyridine through two flexible octyne chains.
The nanovesicles behave like biological membrane by spontaneously self-assembling into “pearl-like” chains and subsequently forming long nanotubes (diameter: 150 nm), which further develop into various types of network-junctions through self-organization.
For drug loading and delivery applications, the nanovesicles were externally protected with biocompatible poly(ethyleneglycol)-2000 to prevent them from fusion and ensuing tube formation.
Nontoxic nature of the nanovesicles was demonstrated by zebrafish teratogenicity assay.
Biocompatible nanovesicles were loaded with “terfenadine” drug and successfully utilized to transport and release drug in sustained manner (up to 72 h) in zebrafish larvae, which is recognized as an emerging in vivo model system.
American Psychological Association (APA)
Botcha, Ajay Kumar& Dulla, Balakrishna& Reddy, E. Ramanjaneya& Chennubhotla, Keerthana S.& Kulkarni, Pushkar& Chandrasekar, Rajadurai…[et al.]. 2014. Organic Nanovesicular Cargoes for Sustained Drug Delivery: Synthesis, Vesicle Formation, Controlling “Pearling” States, and Terfenadine LoadingRelease Studies. Journal of Nanotechnology،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1042198
Modern Language Association (MLA)
Botcha, Ajay Kumar…[et al.]. Organic Nanovesicular Cargoes for Sustained Drug Delivery: Synthesis, Vesicle Formation, Controlling “Pearling” States, and Terfenadine LoadingRelease Studies. Journal of Nanotechnology No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1042198
American Medical Association (AMA)
Botcha, Ajay Kumar& Dulla, Balakrishna& Reddy, E. Ramanjaneya& Chennubhotla, Keerthana S.& Kulkarni, Pushkar& Chandrasekar, Rajadurai…[et al.]. Organic Nanovesicular Cargoes for Sustained Drug Delivery: Synthesis, Vesicle Formation, Controlling “Pearling” States, and Terfenadine LoadingRelease Studies. Journal of Nanotechnology. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1042198
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042198