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Androgen Deprivation Therapy and Cardiovascular Risk in Chinese Patients with Nonmetastatic Carcinoma of Prostate
المؤلفون المشاركون
Huang, Gang
Yeung, Chun-Yip
Lee, Ka Kui
Liu, Jianxiong
Ho, Kwan Lun
Yiu, Ming-Kwong
Lam, Karen Siu-Ling
Tse, Hung-Fat
Siu, Chung-Wah
Yau, Thomas
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-07
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Androgen deprivation therapy (ADT) in nonmetastatic prostate cancer is unclear.
Recent data suggests possible increase in the cardiovascular risks receiving ADT.
The aim of the study was to investigate the cardiovascular outcomes in a cohort of Chinese nonmetastatic prostate cancer patients with no previously documented cardiovascular disease.
Methods and Results.
745 patients with no previously documented cardiovascular disease and/or diabetes mellitus diagnosed to have nonmetastatic prostate cancer were recruited.
Of these, 517 patients received ADT and the remaining 228 did not.
After a mean follow-up of 5.3 years, 60 patients developed primary composite endpoint including (1) coronary artery disease, (2) congestive heart failure, and (3) ischemic stroke.
Higher proportion of patients on ADT (51 patients, 9.9%) developed composite endpoint compared with those not on ADT (9 patients, 3.9%) with hazard ratio (HR) of 2.06 (95% confidence interval (CI): 1.03–3.24, P = 0.04 ).
Furthermore, Cox regression analysis revealed that only the use of ADT (HR: 2.1, 95% CI: 1.03–4.25, P = 0.04 ) and hypertension (HR: 2.0, 95% CI: 1.21–3.33, P < 0.01 ) were independent predictors for primary composite endpoint.
Conclusion.
ADT in Chinese patients with nonmetastatic prostate cancer with no previously documented cardiovascular disease was associated with subsequent development of cardiovascular events.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Gang& Yeung, Chun-Yip& Lee, Ka Kui& Liu, Jianxiong& Ho, Kwan Lun& Yiu, Ming-Kwong…[et al.]. 2014. Androgen Deprivation Therapy and Cardiovascular Risk in Chinese Patients with Nonmetastatic Carcinoma of Prostate. Journal of Oncology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1042250
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Gang…[et al.]. Androgen Deprivation Therapy and Cardiovascular Risk in Chinese Patients with Nonmetastatic Carcinoma of Prostate. Journal of Oncology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1042250
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Gang& Yeung, Chun-Yip& Lee, Ka Kui& Liu, Jianxiong& Ho, Kwan Lun& Yiu, Ming-Kwong…[et al.]. Androgen Deprivation Therapy and Cardiovascular Risk in Chinese Patients with Nonmetastatic Carcinoma of Prostate. Journal of Oncology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1042250
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1042250
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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