Androgen Deprivation Therapy and Cardiovascular Risk in Chinese Patients with Nonmetastatic Carcinoma of Prostate
Joint Authors
Huang, Gang
Yeung, Chun-Yip
Lee, Ka Kui
Liu, Jianxiong
Ho, Kwan Lun
Yiu, Ming-Kwong
Lam, Karen Siu-Ling
Tse, Hung-Fat
Siu, Chung-Wah
Yau, Thomas
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-07
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Androgen deprivation therapy (ADT) in nonmetastatic prostate cancer is unclear.
Recent data suggests possible increase in the cardiovascular risks receiving ADT.
The aim of the study was to investigate the cardiovascular outcomes in a cohort of Chinese nonmetastatic prostate cancer patients with no previously documented cardiovascular disease.
Methods and Results.
745 patients with no previously documented cardiovascular disease and/or diabetes mellitus diagnosed to have nonmetastatic prostate cancer were recruited.
Of these, 517 patients received ADT and the remaining 228 did not.
After a mean follow-up of 5.3 years, 60 patients developed primary composite endpoint including (1) coronary artery disease, (2) congestive heart failure, and (3) ischemic stroke.
Higher proportion of patients on ADT (51 patients, 9.9%) developed composite endpoint compared with those not on ADT (9 patients, 3.9%) with hazard ratio (HR) of 2.06 (95% confidence interval (CI): 1.03–3.24, P = 0.04 ).
Furthermore, Cox regression analysis revealed that only the use of ADT (HR: 2.1, 95% CI: 1.03–4.25, P = 0.04 ) and hypertension (HR: 2.0, 95% CI: 1.21–3.33, P < 0.01 ) were independent predictors for primary composite endpoint.
Conclusion.
ADT in Chinese patients with nonmetastatic prostate cancer with no previously documented cardiovascular disease was associated with subsequent development of cardiovascular events.
American Psychological Association (APA)
Huang, Gang& Yeung, Chun-Yip& Lee, Ka Kui& Liu, Jianxiong& Ho, Kwan Lun& Yiu, Ming-Kwong…[et al.]. 2014. Androgen Deprivation Therapy and Cardiovascular Risk in Chinese Patients with Nonmetastatic Carcinoma of Prostate. Journal of Oncology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1042250
Modern Language Association (MLA)
Huang, Gang…[et al.]. Androgen Deprivation Therapy and Cardiovascular Risk in Chinese Patients with Nonmetastatic Carcinoma of Prostate. Journal of Oncology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1042250
American Medical Association (AMA)
Huang, Gang& Yeung, Chun-Yip& Lee, Ka Kui& Liu, Jianxiong& Ho, Kwan Lun& Yiu, Ming-Kwong…[et al.]. Androgen Deprivation Therapy and Cardiovascular Risk in Chinese Patients with Nonmetastatic Carcinoma of Prostate. Journal of Oncology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1042250
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042250