Evaluation of p53, HoxD10, and E-Cadherin Status in Breast Cancer and Correlation with Histological Grade and Other Prognostic Factors
المؤلفون المشاركون
Sharma, Ankit
Bharti, Jyotsna Naresh
Nigam, Jitendra Singh
Sekar, Preethi
Soni, Priyanka Bhatia
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-30
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Background.
Study of tumor molecular characteristics is necessary to understand both the risk of breast cancer recurrence and the response to therapy.
Aims.
To evaluate p53, HoxD10, and E-cadherin status in breast cancer and to correlate with histological grade and other prognostic factors.
Material and Methods.
The study was conducted in 60 cases of invasive ductal carcinoma NOS with 20 cases belonging to each grade and evaluation of p53 was done by IHC and that of HoxD10 and E Cadherin status by PCR and correlation was done with histological grade and other prognostic factors.
Result.
p53 expression was seen in 71.67% (43/60) of the tumors.
HoxD10 gene was downregulated in 46.67% (28/60) of the tumors.
p53 overexpression and lower HoxD10 mRNA levels showed statistically significant association higher histological grade of the tumor ( P < 0.05 ).
CDH1 gene mutation was seen in 60% (15/25) of the tumors.
No significant association was found between p53 expression, HoxD10 gene, CDH1 gene mutation, and other prognostic factors.
Conclusion.
p53 over expression and lower HoxD10 mRNA levels were found to be significantly associated with higher grade tumours.
This suggests that p53 and HoxD10 gene play an important tumor suppressor role and the loss of which results in breast cancer progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sekar, Preethi& Bharti, Jyotsna Naresh& Nigam, Jitendra Singh& Sharma, Ankit& Soni, Priyanka Bhatia. 2014. Evaluation of p53, HoxD10, and E-Cadherin Status in Breast Cancer and Correlation with Histological Grade and Other Prognostic Factors. Journal of Oncology،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1042273
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sekar, Preethi…[et al.]. Evaluation of p53, HoxD10, and E-Cadherin Status in Breast Cancer and Correlation with Histological Grade and Other Prognostic Factors. Journal of Oncology No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-1042273
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sekar, Preethi& Bharti, Jyotsna Naresh& Nigam, Jitendra Singh& Sharma, Ankit& Soni, Priyanka Bhatia. Evaluation of p53, HoxD10, and E-Cadherin Status in Breast Cancer and Correlation with Histological Grade and Other Prognostic Factors. Journal of Oncology. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1042273
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1042273
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر