Evaluation of p53, HoxD10, and E-Cadherin Status in Breast Cancer and Correlation with Histological Grade and Other Prognostic Factors
Joint Authors
Sharma, Ankit
Bharti, Jyotsna Naresh
Nigam, Jitendra Singh
Sekar, Preethi
Soni, Priyanka Bhatia
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-30
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Study of tumor molecular characteristics is necessary to understand both the risk of breast cancer recurrence and the response to therapy.
Aims.
To evaluate p53, HoxD10, and E-cadherin status in breast cancer and to correlate with histological grade and other prognostic factors.
Material and Methods.
The study was conducted in 60 cases of invasive ductal carcinoma NOS with 20 cases belonging to each grade and evaluation of p53 was done by IHC and that of HoxD10 and E Cadherin status by PCR and correlation was done with histological grade and other prognostic factors.
Result.
p53 expression was seen in 71.67% (43/60) of the tumors.
HoxD10 gene was downregulated in 46.67% (28/60) of the tumors.
p53 overexpression and lower HoxD10 mRNA levels showed statistically significant association higher histological grade of the tumor ( P < 0.05 ).
CDH1 gene mutation was seen in 60% (15/25) of the tumors.
No significant association was found between p53 expression, HoxD10 gene, CDH1 gene mutation, and other prognostic factors.
Conclusion.
p53 over expression and lower HoxD10 mRNA levels were found to be significantly associated with higher grade tumours.
This suggests that p53 and HoxD10 gene play an important tumor suppressor role and the loss of which results in breast cancer progression.
American Psychological Association (APA)
Sekar, Preethi& Bharti, Jyotsna Naresh& Nigam, Jitendra Singh& Sharma, Ankit& Soni, Priyanka Bhatia. 2014. Evaluation of p53, HoxD10, and E-Cadherin Status in Breast Cancer and Correlation with Histological Grade and Other Prognostic Factors. Journal of Oncology،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1042273
Modern Language Association (MLA)
Sekar, Preethi…[et al.]. Evaluation of p53, HoxD10, and E-Cadherin Status in Breast Cancer and Correlation with Histological Grade and Other Prognostic Factors. Journal of Oncology No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-1042273
American Medical Association (AMA)
Sekar, Preethi& Bharti, Jyotsna Naresh& Nigam, Jitendra Singh& Sharma, Ankit& Soni, Priyanka Bhatia. Evaluation of p53, HoxD10, and E-Cadherin Status in Breast Cancer and Correlation with Histological Grade and Other Prognostic Factors. Journal of Oncology. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1042273
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042273