Nuclear Pattern of CXCR4 Expression Is Associated with a Better Overall Survival in Patients with Gastric Cancer
المؤلفون المشاركون
Nikkhoo, Bahram
Jalili, Ali
Fakhari, Shohreh
Sheikhesmaili, Farshad
Fathi, Fardin
Rooshani, Daem
Hoseinpour Feizi, Mohammad Ali
Nikzaban, Mehrnoush
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-10
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Introduction.
Previous studies have shown that stromal-derived factor-1 (CXCL12) and its receptor, CXCR4, play a crucial role in metastasis of various tumors.
Similarly, it has been cleared that CXCR4 is expressed on the cell surface of gastric cancers.
However, nuclear expression of CXCR4 and its clinical importance have not been yet studied.
Materials and Methods.
Herein, we studied the expression of CXCR4 in gastric samples from patients with gastric adenocarcinoma as well as human gastric carcinoma cell line, AGS, by employing RT-PCR, immunohistochemistry, and flow cytometry techniques.
Results.
RT-PCR data showed that CXCR4 is highly expressed on AGS cells.
This was confirmed by IHC and FACS as CXCR4 was detected on cell membrane, in cytoplasm, and in nucleus of AGS cells.
Moreover, we found that both cytoplasmic and nuclear CXCR4 are strongly expressed in primary gastric cancer and the cytoplasmic pattern of CXCR4 tends to be associated with a shorter overall survival than nuclear staining.
In conclusion, we present evidence for the first time that both cytoplasmic and nuclear expression of CXCR4 are detectable in gastric cancer tissues.
However, the role of both cytoplasmic and nuclear CXCR4 needs to be further elucidated.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nikkhoo, Bahram& Jalili, Ali& Fakhari, Shohreh& Sheikhesmaili, Farshad& Fathi, Fardin& Rooshani, Daem…[et al.]. 2014. Nuclear Pattern of CXCR4 Expression Is Associated with a Better Overall Survival in Patients with Gastric Cancer. Journal of Oncology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042285
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nikkhoo, Bahram…[et al.]. Nuclear Pattern of CXCR4 Expression Is Associated with a Better Overall Survival in Patients with Gastric Cancer. Journal of Oncology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1042285
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nikkhoo, Bahram& Jalili, Ali& Fakhari, Shohreh& Sheikhesmaili, Farshad& Fathi, Fardin& Rooshani, Daem…[et al.]. Nuclear Pattern of CXCR4 Expression Is Associated with a Better Overall Survival in Patients with Gastric Cancer. Journal of Oncology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042285
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1042285
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر