A New Combination Formula for Treatment of Fungal Keratitis: An Experimental Study
المؤلفون المشاركون
El-Mofty, Hala Mohamed
Abdelhakim, Mohamad Amr Salah Eddin
El-Miligi, Mohamed Farid
El-Nabarawi, Mohamed A.
Khalil, Islam Ahmed Hamed
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-29
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
To formulate and evaluate slow release ketoconazole and ketorolac to treat fungal keratitis and associated inflammation.
Methods.
Experimental study with the following outcome measures.
Pharmaceutical Evaluation.
Mucoadhesive gels containing ketoconazole and ketorolac were used.
Microbiological in vitro evaluation was performed using cup method.
In vivo evaluation was performed on 24 rabbits divided into 2 groups, 12 rabbits each, group A (fast release formula; 6 times daily) and group B (slow release formula; 3 times daily).
Each group was divided into two subgroups (6 rabbits each).
Both eyes of rabbits were inoculated with Candida albicans.
The left eye of all rabbits received the combination formulae.
The right eye for one subgroup received ketoconazole as control 1 while the other subgroup received placebo as control 2.
Clinical follow-up was done and, finally, the corneas were used for microbiological and pathological evaluation.
Results.
Gels containing high polymer concentration showed both high viscosity and mucoadhesion properties with slower drug release.
The infected eyes treated with slow release formula containing both drugs showed better curing of the cornea and pathologically less inflammation than eyes treated with fast release formula.
Conclusion.
Slow release formula containing ketoconazole and ketorolac showed higher activity than fast release formula against fungal keratitis and associated inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
El-Mofty, Hala Mohamed& Abdelhakim, Mohamad Amr Salah Eddin& El-Miligi, Mohamed Farid& El-Nabarawi, Mohamed A.& Khalil, Islam Ahmed Hamed. 2014. A New Combination Formula for Treatment of Fungal Keratitis: An Experimental Study. Journal of Ophthalmology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042419
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
El-Mofty, Hala Mohamed…[et al.]. A New Combination Formula for Treatment of Fungal Keratitis: An Experimental Study. Journal of Ophthalmology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1042419
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
El-Mofty, Hala Mohamed& Abdelhakim, Mohamad Amr Salah Eddin& El-Miligi, Mohamed Farid& El-Nabarawi, Mohamed A.& Khalil, Islam Ahmed Hamed. A New Combination Formula for Treatment of Fungal Keratitis: An Experimental Study. Journal of Ophthalmology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042419
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1042419
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر