A New Combination Formula for Treatment of Fungal Keratitis: An Experimental Study
Joint Authors
El-Mofty, Hala Mohamed
Abdelhakim, Mohamad Amr Salah Eddin
El-Miligi, Mohamed Farid
El-Nabarawi, Mohamed A.
Khalil, Islam Ahmed Hamed
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
To formulate and evaluate slow release ketoconazole and ketorolac to treat fungal keratitis and associated inflammation.
Methods.
Experimental study with the following outcome measures.
Pharmaceutical Evaluation.
Mucoadhesive gels containing ketoconazole and ketorolac were used.
Microbiological in vitro evaluation was performed using cup method.
In vivo evaluation was performed on 24 rabbits divided into 2 groups, 12 rabbits each, group A (fast release formula; 6 times daily) and group B (slow release formula; 3 times daily).
Each group was divided into two subgroups (6 rabbits each).
Both eyes of rabbits were inoculated with Candida albicans.
The left eye of all rabbits received the combination formulae.
The right eye for one subgroup received ketoconazole as control 1 while the other subgroup received placebo as control 2.
Clinical follow-up was done and, finally, the corneas were used for microbiological and pathological evaluation.
Results.
Gels containing high polymer concentration showed both high viscosity and mucoadhesion properties with slower drug release.
The infected eyes treated with slow release formula containing both drugs showed better curing of the cornea and pathologically less inflammation than eyes treated with fast release formula.
Conclusion.
Slow release formula containing ketoconazole and ketorolac showed higher activity than fast release formula against fungal keratitis and associated inflammation.
American Psychological Association (APA)
El-Mofty, Hala Mohamed& Abdelhakim, Mohamad Amr Salah Eddin& El-Miligi, Mohamed Farid& El-Nabarawi, Mohamed A.& Khalil, Islam Ahmed Hamed. 2014. A New Combination Formula for Treatment of Fungal Keratitis: An Experimental Study. Journal of Ophthalmology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042419
Modern Language Association (MLA)
El-Mofty, Hala Mohamed…[et al.]. A New Combination Formula for Treatment of Fungal Keratitis: An Experimental Study. Journal of Ophthalmology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1042419
American Medical Association (AMA)
El-Mofty, Hala Mohamed& Abdelhakim, Mohamad Amr Salah Eddin& El-Miligi, Mohamed Farid& El-Nabarawi, Mohamed A.& Khalil, Islam Ahmed Hamed. A New Combination Formula for Treatment of Fungal Keratitis: An Experimental Study. Journal of Ophthalmology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042419
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042419