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Inhibition of Corneal Neovascularization by Topical and Subconjunctival Tigecycline
المؤلفون المشاركون
Goktas, Sertan
Erdogan, Ender
Sakarya, Rabia
Sakarya, Yasar
Yılmaz, Mustafa
Ozcimen, Muammer
Unlukal, Nejat
Alpfidan, Ismail
Tas, Fatih
Erdogan, Erkan
Bukus, Abdulkadir
Ivacık, Ismail Senol
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-14
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the effects of topical and subconjunctival tigecycline on the prevention of corneal neovascularization.
Materials and Methods.
Following chemical burn, thirty-two rats were treated daily with topical instillation of 1 mg/mL tigecycline (group 1) or subconjunctival instillation of 1 mg/mL tigecycline (group 3) for 7 days.
Control rats received topical (group 2) or subconjunctival (group 4) 0.9% saline.
Digital photographs of the cornea were taken on the eighth day after treatment and analyzed to determine the percentage area of the cornea covered by neovascularization.
Corneal sections were analyzed histopathologically.
Results.
The median percentages of corneal neovascularization in groups 1 and 3 were 48% (95% confidence interval (CI), 44.2–55.8%) and 33.5% (95% CI, 26.6–39.2%), respectively.
The median percentages of corneal neovascularization of groups 1 and 3 were significantly lower than that of the control group ( P = 0.03 and P < 0.001 , resp.).
Histologic examination of samples from groups 1 and 3 showed lower vascularity than that of control groups.
Conclusion.
Topical and subconjunctival administration of tigecycline seems to be showing promising therapeutic effects on the prevention of corneal neovascularization.
Furthermore, subconjunctival administration of tigecycline is more potent than topical administration in the inhibition of corneal neovascularization.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Goktas, Sertan& Erdogan, Ender& Sakarya, Rabia& Sakarya, Yasar& Yılmaz, Mustafa& Ozcimen, Muammer…[et al.]. 2014. Inhibition of Corneal Neovascularization by Topical and Subconjunctival Tigecycline. Journal of Ophthalmology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1042505
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Goktas, Sertan…[et al.]. Inhibition of Corneal Neovascularization by Topical and Subconjunctival Tigecycline. Journal of Ophthalmology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1042505
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Goktas, Sertan& Erdogan, Ender& Sakarya, Rabia& Sakarya, Yasar& Yılmaz, Mustafa& Ozcimen, Muammer…[et al.]. Inhibition of Corneal Neovascularization by Topical and Subconjunctival Tigecycline. Journal of Ophthalmology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1042505
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1042505
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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