Inhibition of Corneal Neovascularization by Topical and Subconjunctival Tigecycline
Joint Authors
Goktas, Sertan
Erdogan, Ender
Sakarya, Rabia
Sakarya, Yasar
Yılmaz, Mustafa
Ozcimen, Muammer
Unlukal, Nejat
Alpfidan, Ismail
Tas, Fatih
Erdogan, Erkan
Bukus, Abdulkadir
Ivacık, Ismail Senol
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
To investigate the effects of topical and subconjunctival tigecycline on the prevention of corneal neovascularization.
Materials and Methods.
Following chemical burn, thirty-two rats were treated daily with topical instillation of 1 mg/mL tigecycline (group 1) or subconjunctival instillation of 1 mg/mL tigecycline (group 3) for 7 days.
Control rats received topical (group 2) or subconjunctival (group 4) 0.9% saline.
Digital photographs of the cornea were taken on the eighth day after treatment and analyzed to determine the percentage area of the cornea covered by neovascularization.
Corneal sections were analyzed histopathologically.
Results.
The median percentages of corneal neovascularization in groups 1 and 3 were 48% (95% confidence interval (CI), 44.2–55.8%) and 33.5% (95% CI, 26.6–39.2%), respectively.
The median percentages of corneal neovascularization of groups 1 and 3 were significantly lower than that of the control group ( P = 0.03 and P < 0.001 , resp.).
Histologic examination of samples from groups 1 and 3 showed lower vascularity than that of control groups.
Conclusion.
Topical and subconjunctival administration of tigecycline seems to be showing promising therapeutic effects on the prevention of corneal neovascularization.
Furthermore, subconjunctival administration of tigecycline is more potent than topical administration in the inhibition of corneal neovascularization.
American Psychological Association (APA)
Goktas, Sertan& Erdogan, Ender& Sakarya, Rabia& Sakarya, Yasar& Yılmaz, Mustafa& Ozcimen, Muammer…[et al.]. 2014. Inhibition of Corneal Neovascularization by Topical and Subconjunctival Tigecycline. Journal of Ophthalmology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1042505
Modern Language Association (MLA)
Goktas, Sertan…[et al.]. Inhibition of Corneal Neovascularization by Topical and Subconjunctival Tigecycline. Journal of Ophthalmology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1042505
American Medical Association (AMA)
Goktas, Sertan& Erdogan, Ender& Sakarya, Rabia& Sakarya, Yasar& Yılmaz, Mustafa& Ozcimen, Muammer…[et al.]. Inhibition of Corneal Neovascularization by Topical and Subconjunctival Tigecycline. Journal of Ophthalmology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1042505
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042505