Age-Related Macular Degeneration: Insights into Inflammatory Genes

المؤلفون المشاركون

Cascella, Raffaella
Ragazzo, Michele
Strafella, Claudia
Missiroli, Filippo
Borgiani, Paola
Angelucci, Francesco
Marsella, Luigi Tonino
Cusumano, Andrea
Novelli, Giuseppe
Ricci, Federico
Giardina, Emiliano

المصدر

Journal of Ophthalmology

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-11-12

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

Age-related macular degeneration (AMD) is a progressive neurodegenerative disease that affects approximately 8.7% of elderly people worldwide (>55 years old).

AMD is characterized by a multifactorial aetiology that involves several genetic and environmental risk factors (genes, ageing, smoking, family history, dietary habits, oxidative stress, and hypertension).

In particular, ageing and cigarette smoking (including oxidative compounds and reactive oxygen species) have been shown to significantly increase susceptibility to the disease.

Furthermore, different genes (CFH, CFI, C2, C3, IL-6, IL-8, and ARMS2) that play a crucial role in the inflammatory pathway have been associated with AMD risk.

Several genetic and molecular studies have indicated the participation of inflammatory molecules (cytokines and chemokines), immune cells (macrophages), and complement proteins in the development and progression of the disease.

Taking into consideration the genetic and molecular background, this review highlights the genetic role of inflammatory genes involved in AMD pathogenesis and progression.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Cascella, Raffaella& Ragazzo, Michele& Strafella, Claudia& Missiroli, Filippo& Borgiani, Paola& Angelucci, Francesco…[et al.]. 2014. Age-Related Macular Degeneration: Insights into Inflammatory Genes. Journal of Ophthalmology،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1042580

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Cascella, Raffaella…[et al.]. Age-Related Macular Degeneration: Insights into Inflammatory Genes. Journal of Ophthalmology No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1042580

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Cascella, Raffaella& Ragazzo, Michele& Strafella, Claudia& Missiroli, Filippo& Borgiani, Paola& Angelucci, Francesco…[et al.]. Age-Related Macular Degeneration: Insights into Inflammatory Genes. Journal of Ophthalmology. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1042580

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1042580