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Age-Related Macular Degeneration: Insights into Inflammatory Genes
Joint Authors
Cascella, Raffaella
Ragazzo, Michele
Strafella, Claudia
Missiroli, Filippo
Borgiani, Paola
Angelucci, Francesco
Marsella, Luigi Tonino
Cusumano, Andrea
Novelli, Giuseppe
Ricci, Federico
Giardina, Emiliano
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Age-related macular degeneration (AMD) is a progressive neurodegenerative disease that affects approximately 8.7% of elderly people worldwide (>55 years old).
AMD is characterized by a multifactorial aetiology that involves several genetic and environmental risk factors (genes, ageing, smoking, family history, dietary habits, oxidative stress, and hypertension).
In particular, ageing and cigarette smoking (including oxidative compounds and reactive oxygen species) have been shown to significantly increase susceptibility to the disease.
Furthermore, different genes (CFH, CFI, C2, C3, IL-6, IL-8, and ARMS2) that play a crucial role in the inflammatory pathway have been associated with AMD risk.
Several genetic and molecular studies have indicated the participation of inflammatory molecules (cytokines and chemokines), immune cells (macrophages), and complement proteins in the development and progression of the disease.
Taking into consideration the genetic and molecular background, this review highlights the genetic role of inflammatory genes involved in AMD pathogenesis and progression.
American Psychological Association (APA)
Cascella, Raffaella& Ragazzo, Michele& Strafella, Claudia& Missiroli, Filippo& Borgiani, Paola& Angelucci, Francesco…[et al.]. 2014. Age-Related Macular Degeneration: Insights into Inflammatory Genes. Journal of Ophthalmology،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1042580
Modern Language Association (MLA)
Cascella, Raffaella…[et al.]. Age-Related Macular Degeneration: Insights into Inflammatory Genes. Journal of Ophthalmology No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1042580
American Medical Association (AMA)
Cascella, Raffaella& Ragazzo, Michele& Strafella, Claudia& Missiroli, Filippo& Borgiani, Paola& Angelucci, Francesco…[et al.]. Age-Related Macular Degeneration: Insights into Inflammatory Genes. Journal of Ophthalmology. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1042580
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042580