![](/images/graphics-bg.png)
Methanol Extract of Euchelus asper Prevents Bone Resorption in Ovariectomised Mice Model
المؤلفون المشاركون
Balakrishnan, Babita
Chiplunkar, Shubhada Vivek
Indap, Madhavi Manohar
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-05
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Marine molluscs are widely distributed throughout the world and many bioactive compounds exhibiting antiviral, antitumor, antileukemic, and antibacterial activity have been reported worldwide.
The present study was designed to investigate the beneficial effect of methanol extract of Euchelus asper (EAME) on estrogen deficiency induced osteoporosis in ovariectomised mice model.
Forty-two female Swiss albino mice were randomly assigned into Sham operated (Sham) group and six ovariectomised (OVX) subgroups such as OVX with vehicle (OVX); OVX with estradiol (2 mg/kg/day); OVX with EAME of graded doses (25, 50, 100, and 200 mg/kg/day).
Bone turnover markers like serum alkaline phosphatase (ALP), serum acid phosphatase (ACP), serum calcium, and histological investigations of tibia and uterus were analysed.
Metaphyseal DNA content of the femur bone was also studied.
Antiosteoclastogenic activity of EAME was examined.
Administration of EAME was able to reduce the increased bone turnover markers in the ovariectomised mice.
Histomorphometric analysis revealed an increase in bone trabeculation and restoration of trabecular separation by EAME treatment.
Metaphyseal DNA content of the femur of the OVX mice was increased by EAME administration.
EAME also showed a potent antiosteoclastogenic behaviour.
Thus, the present study reveals that EAME was able to successfully reduce the estrogen deficiency induced bone loss.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Balakrishnan, Babita& Chiplunkar, Shubhada Vivek& Indap, Madhavi Manohar. 2014. Methanol Extract of Euchelus asper Prevents Bone Resorption in Ovariectomised Mice Model. Journal of Osteoporosis،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1042693
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Balakrishnan, Babita…[et al.]. Methanol Extract of Euchelus asper Prevents Bone Resorption in Ovariectomised Mice Model. Journal of Osteoporosis No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1042693
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Balakrishnan, Babita& Chiplunkar, Shubhada Vivek& Indap, Madhavi Manohar. Methanol Extract of Euchelus asper Prevents Bone Resorption in Ovariectomised Mice Model. Journal of Osteoporosis. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1042693
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1042693
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)