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Methanol Extract of Euchelus asper Prevents Bone Resorption in Ovariectomised Mice Model
Joint Authors
Balakrishnan, Babita
Chiplunkar, Shubhada Vivek
Indap, Madhavi Manohar
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Marine molluscs are widely distributed throughout the world and many bioactive compounds exhibiting antiviral, antitumor, antileukemic, and antibacterial activity have been reported worldwide.
The present study was designed to investigate the beneficial effect of methanol extract of Euchelus asper (EAME) on estrogen deficiency induced osteoporosis in ovariectomised mice model.
Forty-two female Swiss albino mice were randomly assigned into Sham operated (Sham) group and six ovariectomised (OVX) subgroups such as OVX with vehicle (OVX); OVX with estradiol (2 mg/kg/day); OVX with EAME of graded doses (25, 50, 100, and 200 mg/kg/day).
Bone turnover markers like serum alkaline phosphatase (ALP), serum acid phosphatase (ACP), serum calcium, and histological investigations of tibia and uterus were analysed.
Metaphyseal DNA content of the femur bone was also studied.
Antiosteoclastogenic activity of EAME was examined.
Administration of EAME was able to reduce the increased bone turnover markers in the ovariectomised mice.
Histomorphometric analysis revealed an increase in bone trabeculation and restoration of trabecular separation by EAME treatment.
Metaphyseal DNA content of the femur of the OVX mice was increased by EAME administration.
EAME also showed a potent antiosteoclastogenic behaviour.
Thus, the present study reveals that EAME was able to successfully reduce the estrogen deficiency induced bone loss.
American Psychological Association (APA)
Balakrishnan, Babita& Chiplunkar, Shubhada Vivek& Indap, Madhavi Manohar. 2014. Methanol Extract of Euchelus asper Prevents Bone Resorption in Ovariectomised Mice Model. Journal of Osteoporosis،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1042693
Modern Language Association (MLA)
Balakrishnan, Babita…[et al.]. Methanol Extract of Euchelus asper Prevents Bone Resorption in Ovariectomised Mice Model. Journal of Osteoporosis No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1042693
American Medical Association (AMA)
Balakrishnan, Babita& Chiplunkar, Shubhada Vivek& Indap, Madhavi Manohar. Methanol Extract of Euchelus asper Prevents Bone Resorption in Ovariectomised Mice Model. Journal of Osteoporosis. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1042693
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042693