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Peak Serum AST Is a Better Predictor of Acute Liver Graft Injury after Liver Transplantation When Adjusted for DonorRecipient BSA Size Mismatch (ASTi)
المؤلفون المشاركون
Fukazawa, Kyota
Pretto, Ernesto A.
Nishida, Seigo
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-09
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Despite the marked advances in the perioperative management of the liver transplant recipient, an assessment of clinically significant graft injury following preservation and reperfusion remains difficult.
In this study, we hypothesized that size-adjusted AST could better approximate real AST values and consequently provide a better reflection of the extent of graft damage, with better sensitivity and specificity than current criteria.
Methods.
We reviewed data on 930 orthotopic liver transplant recipients.
Size-adjusted AST (ASTi) was calculated by dividing peak AST by our previously reported index for donor-recipient size mismatch, the BSAi.
The predictive value of ASTi of primary nonfunction (PNF) and graft survival was assessed by receiver operating characteristic curve, logistic regression, Kaplan-Meier survival, and Cox proportional hazard model.
Results.
Size-adjusted peak AST (ASTi) was significantly associated with subsequent occurrence of PNF and graft failure.
In our study cohort, the prediction of PNF by the combination of ASTi and PT-INR had a higher sensitivity and specificity compared to current UNOS criteria.
Conclusions.
We conclude that size-adjusted AST (ASTi) is a simple, reproducible, and sensitive marker of clinically significant graft damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fukazawa, Kyota& Nishida, Seigo& Pretto, Ernesto A.. 2014. Peak Serum AST Is a Better Predictor of Acute Liver Graft Injury after Liver Transplantation When Adjusted for DonorRecipient BSA Size Mismatch (ASTi). Journal of Transplantation،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043289
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fukazawa, Kyota…[et al.]. Peak Serum AST Is a Better Predictor of Acute Liver Graft Injury after Liver Transplantation When Adjusted for DonorRecipient BSA Size Mismatch (ASTi). Journal of Transplantation No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1043289
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fukazawa, Kyota& Nishida, Seigo& Pretto, Ernesto A.. Peak Serum AST Is a Better Predictor of Acute Liver Graft Injury after Liver Transplantation When Adjusted for DonorRecipient BSA Size Mismatch (ASTi). Journal of Transplantation. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043289
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043289
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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