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Peak Serum AST Is a Better Predictor of Acute Liver Graft Injury after Liver Transplantation When Adjusted for DonorRecipient BSA Size Mismatch (ASTi)
Joint Authors
Fukazawa, Kyota
Pretto, Ernesto A.
Nishida, Seigo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Despite the marked advances in the perioperative management of the liver transplant recipient, an assessment of clinically significant graft injury following preservation and reperfusion remains difficult.
In this study, we hypothesized that size-adjusted AST could better approximate real AST values and consequently provide a better reflection of the extent of graft damage, with better sensitivity and specificity than current criteria.
Methods.
We reviewed data on 930 orthotopic liver transplant recipients.
Size-adjusted AST (ASTi) was calculated by dividing peak AST by our previously reported index for donor-recipient size mismatch, the BSAi.
The predictive value of ASTi of primary nonfunction (PNF) and graft survival was assessed by receiver operating characteristic curve, logistic regression, Kaplan-Meier survival, and Cox proportional hazard model.
Results.
Size-adjusted peak AST (ASTi) was significantly associated with subsequent occurrence of PNF and graft failure.
In our study cohort, the prediction of PNF by the combination of ASTi and PT-INR had a higher sensitivity and specificity compared to current UNOS criteria.
Conclusions.
We conclude that size-adjusted AST (ASTi) is a simple, reproducible, and sensitive marker of clinically significant graft damage.
American Psychological Association (APA)
Fukazawa, Kyota& Nishida, Seigo& Pretto, Ernesto A.. 2014. Peak Serum AST Is a Better Predictor of Acute Liver Graft Injury after Liver Transplantation When Adjusted for DonorRecipient BSA Size Mismatch (ASTi). Journal of Transplantation،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043289
Modern Language Association (MLA)
Fukazawa, Kyota…[et al.]. Peak Serum AST Is a Better Predictor of Acute Liver Graft Injury after Liver Transplantation When Adjusted for DonorRecipient BSA Size Mismatch (ASTi). Journal of Transplantation No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1043289
American Medical Association (AMA)
Fukazawa, Kyota& Nishida, Seigo& Pretto, Ernesto A.. Peak Serum AST Is a Better Predictor of Acute Liver Graft Injury after Liver Transplantation When Adjusted for DonorRecipient BSA Size Mismatch (ASTi). Journal of Transplantation. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043289
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043289