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Plant-Derived Anti-Inflammatory Compounds: Hopes and Disappointments regarding the Translation of Preclinical Knowledge into Clinical Progress
المؤلفون المشاركون
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Many diseases have been described to be associated with inflammatory processes.
The currently available anti-inflammatory drug therapy is often not successful or causes intolerable side effects.
Thus, new anti-inflammatory substances are still urgently needed.
Plants were the first source of remedies in the history of mankind.
Since their chemical characterization in the 19th century, herbal bioactive compounds have fueled drug development.
Also, nowadays, new plant-derived agents continuously enrich our drug arsenal (e.g., vincristine, galantamine, and artemisinin).
The number of new, pharmacologically active herbal ingredients, in particular that of anti-inflammatory compounds, rises continuously.
The major obstacle in this field is the translation of preclinical knowledge into evidence-based clinical progress.
Human trials of good quality are often missing or, when available, are frequently not suitable to really prove a therapeutical value.
This minireview will summarize the current situation of 6 very prominent plant-derived anti-inflammatory compounds: curcumin, colchicine, resveratrol, capsaicin, epigallocatechin-3-gallate (EGCG), and quercetin.
We will highlight their clinical potential and/or pinpoint an overestimation.
Moreover, we will sum up the planned trials in order to provide insights into the inflammatory disorders that are hypothesized to be beneficially influenced by the compound.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fürst, Robert& Zündorf, Ilse. 2014. Plant-Derived Anti-Inflammatory Compounds: Hopes and Disappointments regarding the Translation of Preclinical Knowledge into Clinical Progress. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043343
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fürst, Robert& Zündorf, Ilse. Plant-Derived Anti-Inflammatory Compounds: Hopes and Disappointments regarding the Translation of Preclinical Knowledge into Clinical Progress. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043343
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fürst, Robert& Zündorf, Ilse. Plant-Derived Anti-Inflammatory Compounds: Hopes and Disappointments regarding the Translation of Preclinical Knowledge into Clinical Progress. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043343
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043343
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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