Plant-Derived Anti-Inflammatory Compounds: Hopes and Disappointments regarding the Translation of Preclinical Knowledge into Clinical Progress
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Many diseases have been described to be associated with inflammatory processes.
The currently available anti-inflammatory drug therapy is often not successful or causes intolerable side effects.
Thus, new anti-inflammatory substances are still urgently needed.
Plants were the first source of remedies in the history of mankind.
Since their chemical characterization in the 19th century, herbal bioactive compounds have fueled drug development.
Also, nowadays, new plant-derived agents continuously enrich our drug arsenal (e.g., vincristine, galantamine, and artemisinin).
The number of new, pharmacologically active herbal ingredients, in particular that of anti-inflammatory compounds, rises continuously.
The major obstacle in this field is the translation of preclinical knowledge into evidence-based clinical progress.
Human trials of good quality are often missing or, when available, are frequently not suitable to really prove a therapeutical value.
This minireview will summarize the current situation of 6 very prominent plant-derived anti-inflammatory compounds: curcumin, colchicine, resveratrol, capsaicin, epigallocatechin-3-gallate (EGCG), and quercetin.
We will highlight their clinical potential and/or pinpoint an overestimation.
Moreover, we will sum up the planned trials in order to provide insights into the inflammatory disorders that are hypothesized to be beneficially influenced by the compound.
American Psychological Association (APA)
Fürst, Robert& Zündorf, Ilse. 2014. Plant-Derived Anti-Inflammatory Compounds: Hopes and Disappointments regarding the Translation of Preclinical Knowledge into Clinical Progress. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043343
Modern Language Association (MLA)
Fürst, Robert& Zündorf, Ilse. Plant-Derived Anti-Inflammatory Compounds: Hopes and Disappointments regarding the Translation of Preclinical Knowledge into Clinical Progress. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043343
American Medical Association (AMA)
Fürst, Robert& Zündorf, Ilse. Plant-Derived Anti-Inflammatory Compounds: Hopes and Disappointments regarding the Translation of Preclinical Knowledge into Clinical Progress. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043343
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043343