Gene Expression Profile in Delay Graft Function: Inflammatory Markers Are Associated with Recipient and Donor Risk Factors
المؤلفون المشاركون
Guerrieri, Diego
Re, Luis
Petroni, Jorgelina
Ambrosi, Nella
Pilotti, Roxana E.
Chuluyan, H. Eduardo
Casadei, Domingo
Incardona, Claudio
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-18
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Delayed graft function (DGF) remains an important problem after kidney transplantation and reduced long-term graft survival of the transplanted organ.
The aim of the present study was to determine if the development of DGF was associated with a specific pattern of inflammatory gene expression in expanded criteria of deceased donor kidney transplantation.
Also, we explored the presence of correlations between DGF risk factors and the profile that was found.
Methods.
Seven days after kidney transplant, a cDNA microarray was performed on biopsies of graft from patients with and without DGF.
Data was confirmed by real-time PCR.
Correlations were performed between inflammatory gene expression and clinical risk factors.
Results.
From a total of 84 genes analyzed, 58 genes were upregulated while only 1 gene was downregulated in patients with DGF compared with no DGF (P=0.01).
The most relevant genes fold changes observed was IFNA1, IL-10, IL-1F7, IL-1R1, HMOX-1, and TGF-β.
The results were confirmed for IFNA1, IL-1R1, HMOX-1 and TGF-β.
A correlation was observed between TGF-β, donor age, and preablation creatinine, but not body mass index (BMI).
Also, TGF-β showed an association with recipient age, while IFNA1 correlated with recipient BMI.
Furthermore, TGF-β, IFNA1 and HMOX-1 correlated with several posttransplant kidney function markers, such as diuresis, ultrasound Doppler, and glycemia.
Conclusions.
Overall, the present study shows that DGF is associated with inflammatory markers, which are correlated with donor and recipient DGF risk factors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guerrieri, Diego& Re, Luis& Petroni, Jorgelina& Ambrosi, Nella& Pilotti, Roxana E.& Chuluyan, H. Eduardo…[et al.]. 2014. Gene Expression Profile in Delay Graft Function: Inflammatory Markers Are Associated with Recipient and Donor Risk Factors. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043352
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guerrieri, Diego…[et al.]. Gene Expression Profile in Delay Graft Function: Inflammatory Markers Are Associated with Recipient and Donor Risk Factors. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043352
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guerrieri, Diego& Re, Luis& Petroni, Jorgelina& Ambrosi, Nella& Pilotti, Roxana E.& Chuluyan, H. Eduardo…[et al.]. Gene Expression Profile in Delay Graft Function: Inflammatory Markers Are Associated with Recipient and Donor Risk Factors. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043352
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043352
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر