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Anti-Inflammatory and Antinociceptive Activities of Bufalin in Rodents
المؤلفون المشاركون
Wen, Lili
Huang, Yang
Xie, Xianbiao
Huang, Wan
Yin, Junqiang
Lin, Wenqian
Jia, Qiang
Zeng, Weian
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-26
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The aims of this study were to evaluate the anti-inflammatory and analgesic effects of bufalin, a major component of “Chan-su.” We used a carrageenan-induced paw edema model to assess the anti-inflammatory activity of this compound, and Western blot analysis detected NF-κB signaling during this effect.
The antinociceptive activities were evaluated by acetic acid-induced writhing, formalin, and hot-plate tests; open-field test investigated effects on the central nervous system.
Our data showed that bufalin (0.3 and 0.6 mg/kg, i.p.) potently decreased carrageenan-induced paw edema.
Bufalin down regulated the expression levels of nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) during these treatments.
Further studies demonstrated that bufalin significantly inhibited the activation of NF-κB signaling.
Bufalin also reduced acetic acid-induced writhing and the licking time in the formalin test and increased hot-plate reaction latencies.
Naloxone pretreatment (2 mg/kg, i.p.) in the early phases of the formalin test and hot-plate test significantly attenuated the bufalin-induced antinociception effects, which suggests the involvement of the opioid system.
A reduction in locomotion was not observed in the open-field test after bufalin administration.
Taken together, bufalin treatment resulted in in vivo anti-inflammatory and analgesic effects, and bufalin may be a novel, potential drug for the treatment of inflammatory diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wen, Lili& Huang, Yang& Xie, Xianbiao& Huang, Wan& Yin, Junqiang& Lin, Wenqian…[et al.]. 2014. Anti-Inflammatory and Antinociceptive Activities of Bufalin in Rodents. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043354
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wen, Lili…[et al.]. Anti-Inflammatory and Antinociceptive Activities of Bufalin in Rodents. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043354
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wen, Lili& Huang, Yang& Xie, Xianbiao& Huang, Wan& Yin, Junqiang& Lin, Wenqian…[et al.]. Anti-Inflammatory and Antinociceptive Activities of Bufalin in Rodents. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043354
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043354
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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