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Anti-Inflammatory and Antinociceptive Activities of Bufalin in Rodents
Joint Authors
Wen, Lili
Huang, Yang
Xie, Xianbiao
Huang, Wan
Yin, Junqiang
Lin, Wenqian
Jia, Qiang
Zeng, Weian
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The aims of this study were to evaluate the anti-inflammatory and analgesic effects of bufalin, a major component of “Chan-su.” We used a carrageenan-induced paw edema model to assess the anti-inflammatory activity of this compound, and Western blot analysis detected NF-κB signaling during this effect.
The antinociceptive activities were evaluated by acetic acid-induced writhing, formalin, and hot-plate tests; open-field test investigated effects on the central nervous system.
Our data showed that bufalin (0.3 and 0.6 mg/kg, i.p.) potently decreased carrageenan-induced paw edema.
Bufalin down regulated the expression levels of nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) during these treatments.
Further studies demonstrated that bufalin significantly inhibited the activation of NF-κB signaling.
Bufalin also reduced acetic acid-induced writhing and the licking time in the formalin test and increased hot-plate reaction latencies.
Naloxone pretreatment (2 mg/kg, i.p.) in the early phases of the formalin test and hot-plate test significantly attenuated the bufalin-induced antinociception effects, which suggests the involvement of the opioid system.
A reduction in locomotion was not observed in the open-field test after bufalin administration.
Taken together, bufalin treatment resulted in in vivo anti-inflammatory and analgesic effects, and bufalin may be a novel, potential drug for the treatment of inflammatory diseases.
American Psychological Association (APA)
Wen, Lili& Huang, Yang& Xie, Xianbiao& Huang, Wan& Yin, Junqiang& Lin, Wenqian…[et al.]. 2014. Anti-Inflammatory and Antinociceptive Activities of Bufalin in Rodents. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043354
Modern Language Association (MLA)
Wen, Lili…[et al.]. Anti-Inflammatory and Antinociceptive Activities of Bufalin in Rodents. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043354
American Medical Association (AMA)
Wen, Lili& Huang, Yang& Xie, Xianbiao& Huang, Wan& Yin, Junqiang& Lin, Wenqian…[et al.]. Anti-Inflammatory and Antinociceptive Activities of Bufalin in Rodents. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043354
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043354