The Protective Effects of the Supercritical-Carbon Dioxide Fluid Extract of Chrysanthemum indicum against Lipopolysaccharide-Induced Acute Lung Injury in Mice via Modulating Toll-Like Receptor 4 Signaling Pathway
المؤلفون المشاركون
Chen, Jian-Nan
Su, Zi-Ren
Li, Yu-Cui
Feng, Xue-Xuan
Chen, Zhi-Wei
Zhang, Sai-Xia
Lai, Xiao-Ping
Li, Chu-Wen
Zhang, Xiao-Jun
Wu, Xiao-Li
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-25
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The supercritical-carbon dioxide fluid extract of Chrysanthemum indicum Linné.
(CFE) has been demonstrated to be effective in suppressing inflammation.
The aim of this study is to investigate the preventive action and underlying mechanisms of CFE on acute lung injury (ALI) induced by lipopolysaccharide (LPS) in mice.
ALI was induced by intratracheal instillation of LPS into lung, and dexamethasone was used as a positive control.
Results revealed that pretreatment with CFE abated LPS-induced lung histopathologic changes, reduced the wet/dry ratio and proinflammatory cytokines productions (TNF-α, IL-1β, and IL-6), inhibited inflammatory cells migrations and protein leakages, suppressed the levels of MPO and MDA, and upregulated the abilities of antioxidative enzymes (SOD, CAT, and GPx).
Furthermore, the pretreatment with CFE downregulated the activations of NF-κB and the expressions of TLR4/MyD88.
These results suggested that CFE exerted potential protective effects against LPS-induced ALI in mice and was a potential therapeutic drug for ALI.
Its mechanisms were at least partially associated with the modulations of TLR4 signaling pathways.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Xiao-Li& Feng, Xue-Xuan& Li, Chu-Wen& Zhang, Xiao-Jun& Chen, Zhi-Wei& Chen, Jian-Nan…[et al.]. 2014. The Protective Effects of the Supercritical-Carbon Dioxide Fluid Extract of Chrysanthemum indicum against Lipopolysaccharide-Induced Acute Lung Injury in Mice via Modulating Toll-Like Receptor 4 Signaling Pathway. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1043400
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Xiao-Li…[et al.]. The Protective Effects of the Supercritical-Carbon Dioxide Fluid Extract of Chrysanthemum indicum against Lipopolysaccharide-Induced Acute Lung Injury in Mice via Modulating Toll-Like Receptor 4 Signaling Pathway. Mediators of Inflammation No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1043400
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Xiao-Li& Feng, Xue-Xuan& Li, Chu-Wen& Zhang, Xiao-Jun& Chen, Zhi-Wei& Chen, Jian-Nan…[et al.]. The Protective Effects of the Supercritical-Carbon Dioxide Fluid Extract of Chrysanthemum indicum against Lipopolysaccharide-Induced Acute Lung Injury in Mice via Modulating Toll-Like Receptor 4 Signaling Pathway. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1043400
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043400
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر