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The Protective Effects of the Supercritical-Carbon Dioxide Fluid Extract of Chrysanthemum indicum against Lipopolysaccharide-Induced Acute Lung Injury in Mice via Modulating Toll-Like Receptor 4 Signaling Pathway
Joint Authors
Chen, Jian-Nan
Su, Zi-Ren
Li, Yu-Cui
Feng, Xue-Xuan
Chen, Zhi-Wei
Zhang, Sai-Xia
Lai, Xiao-Ping
Li, Chu-Wen
Zhang, Xiao-Jun
Wu, Xiao-Li
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-25
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The supercritical-carbon dioxide fluid extract of Chrysanthemum indicum Linné.
(CFE) has been demonstrated to be effective in suppressing inflammation.
The aim of this study is to investigate the preventive action and underlying mechanisms of CFE on acute lung injury (ALI) induced by lipopolysaccharide (LPS) in mice.
ALI was induced by intratracheal instillation of LPS into lung, and dexamethasone was used as a positive control.
Results revealed that pretreatment with CFE abated LPS-induced lung histopathologic changes, reduced the wet/dry ratio and proinflammatory cytokines productions (TNF-α, IL-1β, and IL-6), inhibited inflammatory cells migrations and protein leakages, suppressed the levels of MPO and MDA, and upregulated the abilities of antioxidative enzymes (SOD, CAT, and GPx).
Furthermore, the pretreatment with CFE downregulated the activations of NF-κB and the expressions of TLR4/MyD88.
These results suggested that CFE exerted potential protective effects against LPS-induced ALI in mice and was a potential therapeutic drug for ALI.
Its mechanisms were at least partially associated with the modulations of TLR4 signaling pathways.
American Psychological Association (APA)
Wu, Xiao-Li& Feng, Xue-Xuan& Li, Chu-Wen& Zhang, Xiao-Jun& Chen, Zhi-Wei& Chen, Jian-Nan…[et al.]. 2014. The Protective Effects of the Supercritical-Carbon Dioxide Fluid Extract of Chrysanthemum indicum against Lipopolysaccharide-Induced Acute Lung Injury in Mice via Modulating Toll-Like Receptor 4 Signaling Pathway. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1043400
Modern Language Association (MLA)
Wu, Xiao-Li…[et al.]. The Protective Effects of the Supercritical-Carbon Dioxide Fluid Extract of Chrysanthemum indicum against Lipopolysaccharide-Induced Acute Lung Injury in Mice via Modulating Toll-Like Receptor 4 Signaling Pathway. Mediators of Inflammation No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1043400
American Medical Association (AMA)
Wu, Xiao-Li& Feng, Xue-Xuan& Li, Chu-Wen& Zhang, Xiao-Jun& Chen, Zhi-Wei& Chen, Jian-Nan…[et al.]. The Protective Effects of the Supercritical-Carbon Dioxide Fluid Extract of Chrysanthemum indicum against Lipopolysaccharide-Induced Acute Lung Injury in Mice via Modulating Toll-Like Receptor 4 Signaling Pathway. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1043400
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043400