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Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN-γ and CD40-CD40L Interactions
المؤلفون المشاركون
Cunha-Neto, Edecio
Camargo, Ludmila
Rizzo, Luiz Vicente
Abel, Lúcia Cristina Jamli
Cunha Navarro, Isabela
Baron, Monique Andrade
Gazzinelli, Ricardo Tostes
Kalil, Jorge
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-09
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi (T.
cruzi), is characterized by immunopathology driven by IFN-γ secreting Th1-like T cells.
T.
cruzi has a thick coat of mucin-like glycoproteins covering its surface, which plays an important role in parasite invasion and host immunomodulation.
It has been extensively described that T.
cruzi or its products—like GPI anchors isolated from GPI-anchored mucins from the trypomastigote life cycle stage (tGPI-mucins)—are potent inducers of proinflammatory responses (i.e., cytokines and NO production) by IFN-γ primed murine macrophages.
However, little is known about whether T.
cruzi or GPI-mucins exert a similar action in human cells.
We therefore decided to further investigate the in vitro cytokine production profile from human mononuclear cells from uninfected donors exposed to T.
cruzi as well as tGPI-mucins.
We observed that both living T.
cruzi trypomastigotes and tGPI-mucins are potent inducers of IL-12 by human peripheral blood monocytes and this effect depends on CD40-CD40L interaction and IFN-γ.
Our findings suggest that the polarized T1-type cytokine profile seen in T.
cruzi infected patients might be a long-term effect of IL-12 production induced by lifelong exposure to T.
cruzi tGPI-mucins.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abel, Lúcia Cristina Jamli& Camargo, Ludmila& Cunha Navarro, Isabela& Baron, Monique Andrade& Kalil, Jorge& Gazzinelli, Ricardo Tostes…[et al.]. 2014. Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN-γ and CD40-CD40L Interactions. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043494
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abel, Lúcia Cristina Jamli…[et al.]. Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN-γ and CD40-CD40L Interactions. Mediators of Inflammation No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1043494
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abel, Lúcia Cristina Jamli& Camargo, Ludmila& Cunha Navarro, Isabela& Baron, Monique Andrade& Kalil, Jorge& Gazzinelli, Ricardo Tostes…[et al.]. Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN-γ and CD40-CD40L Interactions. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043494
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043494
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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