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Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN-γ and CD40-CD40L Interactions
Joint Authors
Cunha-Neto, Edecio
Camargo, Ludmila
Rizzo, Luiz Vicente
Abel, Lúcia Cristina Jamli
Cunha Navarro, Isabela
Baron, Monique Andrade
Gazzinelli, Ricardo Tostes
Kalil, Jorge
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi (T.
cruzi), is characterized by immunopathology driven by IFN-γ secreting Th1-like T cells.
T.
cruzi has a thick coat of mucin-like glycoproteins covering its surface, which plays an important role in parasite invasion and host immunomodulation.
It has been extensively described that T.
cruzi or its products—like GPI anchors isolated from GPI-anchored mucins from the trypomastigote life cycle stage (tGPI-mucins)—are potent inducers of proinflammatory responses (i.e., cytokines and NO production) by IFN-γ primed murine macrophages.
However, little is known about whether T.
cruzi or GPI-mucins exert a similar action in human cells.
We therefore decided to further investigate the in vitro cytokine production profile from human mononuclear cells from uninfected donors exposed to T.
cruzi as well as tGPI-mucins.
We observed that both living T.
cruzi trypomastigotes and tGPI-mucins are potent inducers of IL-12 by human peripheral blood monocytes and this effect depends on CD40-CD40L interaction and IFN-γ.
Our findings suggest that the polarized T1-type cytokine profile seen in T.
cruzi infected patients might be a long-term effect of IL-12 production induced by lifelong exposure to T.
cruzi tGPI-mucins.
American Psychological Association (APA)
Abel, Lúcia Cristina Jamli& Camargo, Ludmila& Cunha Navarro, Isabela& Baron, Monique Andrade& Kalil, Jorge& Gazzinelli, Ricardo Tostes…[et al.]. 2014. Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN-γ and CD40-CD40L Interactions. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043494
Modern Language Association (MLA)
Abel, Lúcia Cristina Jamli…[et al.]. Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN-γ and CD40-CD40L Interactions. Mediators of Inflammation No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1043494
American Medical Association (AMA)
Abel, Lúcia Cristina Jamli& Camargo, Ludmila& Cunha Navarro, Isabela& Baron, Monique Andrade& Kalil, Jorge& Gazzinelli, Ricardo Tostes…[et al.]. Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN-γ and CD40-CD40L Interactions. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043494
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043494