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The Influence of Autologous Bone Marrow Stem Cell Transplantation on Matrix Metalloproteinases in Patients Treated for Acute ST-Elevation Myocardial Infarction
المؤلفون المشاركون
Furenes, Eline Bredal
Opstad, Trine Baur
Solheim, Svein
Lunde, Ketil
Arnesen, Harald
Seljeflot, Ingebjørg
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-09-11
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Matrix metalloproteinase-9 (MMP-9), regulated by tissue inhibitor of metalloproteinase-9 (TIMP-1) and the extracellular matrix metalloproteinase inducer (EMMPRIN), contributes to plaque instability.
Autologous stem cells from bone marrow (mBMC) treatment are suggested to reduce myocardial damage; however, limited data exists on the influence of mBMC on MMPs.
Aim.
We investigated the influence of mBMC on circulating levels of MMP-9, TIMP-1, and EMMPRIN at different time points in patients included in the randomized Autologous Stem-Cell Transplantation in Acute Myocardial Infarction (ASTAMI) trial ( n = 100 ).
Gene expression analyses were additionally performed.
Results.
After 2-3 weeks we observed a more pronounced increase in MMP-9 levels in the mBMC group, compared to controls ( P = 0.030 ), whereas EMMPRIN levels were reduced from baseline to 2-3 weeks and 3 months in both groups ( P < 0.0001 ).
Gene expression of both MMP-9 and EMMPRIN was reduced from baseline to 3 months.
MMP-9 and EMMPRIN were significantly correlated to myocardial injury (CK: P = 0.005 and P < 0.001 , resp.) and infarct size (SPECT: P = 0.018 and P = 0.008 , resp.).
Conclusion.
The results indicate that the regulation of metalloproteinases is important during AMI, however, limited influenced by mBMC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Furenes, Eline Bredal& Opstad, Trine Baur& Solheim, Svein& Lunde, Ketil& Arnesen, Harald& Seljeflot, Ingebjørg. 2014. The Influence of Autologous Bone Marrow Stem Cell Transplantation on Matrix Metalloproteinases in Patients Treated for Acute ST-Elevation Myocardial Infarction. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043519
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Furenes, Eline Bredal…[et al.]. The Influence of Autologous Bone Marrow Stem Cell Transplantation on Matrix Metalloproteinases in Patients Treated for Acute ST-Elevation Myocardial Infarction. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043519
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Furenes, Eline Bredal& Opstad, Trine Baur& Solheim, Svein& Lunde, Ketil& Arnesen, Harald& Seljeflot, Ingebjørg. The Influence of Autologous Bone Marrow Stem Cell Transplantation on Matrix Metalloproteinases in Patients Treated for Acute ST-Elevation Myocardial Infarction. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043519
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043519
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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