The Influence of Autologous Bone Marrow Stem Cell Transplantation on Matrix Metalloproteinases in Patients Treated for Acute ST-Elevation Myocardial Infarction
المؤلفون المشاركون
Furenes, Eline Bredal
Opstad, Trine Baur
Solheim, Svein
Lunde, Ketil
Arnesen, Harald
Seljeflot, Ingebjørg
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-09-11
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Matrix metalloproteinase-9 (MMP-9), regulated by tissue inhibitor of metalloproteinase-9 (TIMP-1) and the extracellular matrix metalloproteinase inducer (EMMPRIN), contributes to plaque instability.
Autologous stem cells from bone marrow (mBMC) treatment are suggested to reduce myocardial damage; however, limited data exists on the influence of mBMC on MMPs.
Aim.
We investigated the influence of mBMC on circulating levels of MMP-9, TIMP-1, and EMMPRIN at different time points in patients included in the randomized Autologous Stem-Cell Transplantation in Acute Myocardial Infarction (ASTAMI) trial ( n = 100 ).
Gene expression analyses were additionally performed.
Results.
After 2-3 weeks we observed a more pronounced increase in MMP-9 levels in the mBMC group, compared to controls ( P = 0.030 ), whereas EMMPRIN levels were reduced from baseline to 2-3 weeks and 3 months in both groups ( P < 0.0001 ).
Gene expression of both MMP-9 and EMMPRIN was reduced from baseline to 3 months.
MMP-9 and EMMPRIN were significantly correlated to myocardial injury (CK: P = 0.005 and P < 0.001 , resp.) and infarct size (SPECT: P = 0.018 and P = 0.008 , resp.).
Conclusion.
The results indicate that the regulation of metalloproteinases is important during AMI, however, limited influenced by mBMC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Furenes, Eline Bredal& Opstad, Trine Baur& Solheim, Svein& Lunde, Ketil& Arnesen, Harald& Seljeflot, Ingebjørg. 2014. The Influence of Autologous Bone Marrow Stem Cell Transplantation on Matrix Metalloproteinases in Patients Treated for Acute ST-Elevation Myocardial Infarction. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043519
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Furenes, Eline Bredal…[et al.]. The Influence of Autologous Bone Marrow Stem Cell Transplantation on Matrix Metalloproteinases in Patients Treated for Acute ST-Elevation Myocardial Infarction. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043519
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Furenes, Eline Bredal& Opstad, Trine Baur& Solheim, Svein& Lunde, Ketil& Arnesen, Harald& Seljeflot, Ingebjørg. The Influence of Autologous Bone Marrow Stem Cell Transplantation on Matrix Metalloproteinases in Patients Treated for Acute ST-Elevation Myocardial Infarction. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043519
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043519
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر