The Influence of Autologous Bone Marrow Stem Cell Transplantation on Matrix Metalloproteinases in Patients Treated for Acute ST-Elevation Myocardial Infarction
Joint Authors
Furenes, Eline Bredal
Opstad, Trine Baur
Solheim, Svein
Lunde, Ketil
Arnesen, Harald
Seljeflot, Ingebjørg
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Matrix metalloproteinase-9 (MMP-9), regulated by tissue inhibitor of metalloproteinase-9 (TIMP-1) and the extracellular matrix metalloproteinase inducer (EMMPRIN), contributes to plaque instability.
Autologous stem cells from bone marrow (mBMC) treatment are suggested to reduce myocardial damage; however, limited data exists on the influence of mBMC on MMPs.
Aim.
We investigated the influence of mBMC on circulating levels of MMP-9, TIMP-1, and EMMPRIN at different time points in patients included in the randomized Autologous Stem-Cell Transplantation in Acute Myocardial Infarction (ASTAMI) trial ( n = 100 ).
Gene expression analyses were additionally performed.
Results.
After 2-3 weeks we observed a more pronounced increase in MMP-9 levels in the mBMC group, compared to controls ( P = 0.030 ), whereas EMMPRIN levels were reduced from baseline to 2-3 weeks and 3 months in both groups ( P < 0.0001 ).
Gene expression of both MMP-9 and EMMPRIN was reduced from baseline to 3 months.
MMP-9 and EMMPRIN were significantly correlated to myocardial injury (CK: P = 0.005 and P < 0.001 , resp.) and infarct size (SPECT: P = 0.018 and P = 0.008 , resp.).
Conclusion.
The results indicate that the regulation of metalloproteinases is important during AMI, however, limited influenced by mBMC.
American Psychological Association (APA)
Furenes, Eline Bredal& Opstad, Trine Baur& Solheim, Svein& Lunde, Ketil& Arnesen, Harald& Seljeflot, Ingebjørg. 2014. The Influence of Autologous Bone Marrow Stem Cell Transplantation on Matrix Metalloproteinases in Patients Treated for Acute ST-Elevation Myocardial Infarction. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043519
Modern Language Association (MLA)
Furenes, Eline Bredal…[et al.]. The Influence of Autologous Bone Marrow Stem Cell Transplantation on Matrix Metalloproteinases in Patients Treated for Acute ST-Elevation Myocardial Infarction. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043519
American Medical Association (AMA)
Furenes, Eline Bredal& Opstad, Trine Baur& Solheim, Svein& Lunde, Ketil& Arnesen, Harald& Seljeflot, Ingebjørg. The Influence of Autologous Bone Marrow Stem Cell Transplantation on Matrix Metalloproteinases in Patients Treated for Acute ST-Elevation Myocardial Infarction. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043519
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043519