Association of Myeloid Cells of Triggering Receptor-1 with Left Ventricular Systolic Dysfunction in BALBc Mice with Sepsis
المؤلفون المشاركون
Yao, Huaguo
Deng, Liehua
Zhou, Gaosheng
Ye, Lijun
Zhang, Liang
Zhang, Liangqing
Zhang, Yuanli
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-15
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the correlation between TREM-1 and LPS-induced left ventricular systolic dysfunction in BALB/c mice.
Methods.
Male BALB/c mice were randomly divided into 3 groups: LPS, LPS/TREM-1, and control groups which were injected intraperitoneally with 25 mg/kg LPS, 5 μg TREM-1mAb 1 h after LPS challenge, and sterilized normal saline, respectively.
Left ventricular systolic function was monitored by echocardiography at 6 h, 12 h, and 24 h.
Meanwhile, TNF-α, IL-1β, and sTREM-1 in serum and myocardium were determined by ELISA or real-time PCR; at last left ventricles were taken for light microscopy examination.
Results.
FS and EF in LPS/mAbTREM-1 group, significantly declined compared with LPS and control group at 12 h, were accompanied with a markedly increase in serum IL-1β (at 6 h) and sTREM-1 (at 12 h and 24 h) expression.
Myocardium TNF-α (at 6 h and 24 h) and sTREM-1 (at 6 h) were significantly higher in LPS/mAbTrem-1-treated mice than in time-matched LPS-treated mice; meanwhile myocardium TNF-α mRNA were markedly increased in comparison with LPS-treated or saline-treated mice at 24 h.
Besides, mAbTREM-1 aggravated LPS-induced myocardial damage was observed.
Conclusions.
Our results suggest that TREM-1 is significantly associated with LPS-induced left ventricular systolic dysfunction in BALB/c mice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhou, Gaosheng& Ye, Lijun& Zhang, Liang& Zhang, Liangqing& Zhang, Yuanli& Deng, Liehua…[et al.]. 2014. Association of Myeloid Cells of Triggering Receptor-1 with Left Ventricular Systolic Dysfunction in BALBc Mice with Sepsis. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043533
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhou, Gaosheng…[et al.]. Association of Myeloid Cells of Triggering Receptor-1 with Left Ventricular Systolic Dysfunction in BALBc Mice with Sepsis. Mediators of Inflammation No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1043533
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhou, Gaosheng& Ye, Lijun& Zhang, Liang& Zhang, Liangqing& Zhang, Yuanli& Deng, Liehua…[et al.]. Association of Myeloid Cells of Triggering Receptor-1 with Left Ventricular Systolic Dysfunction in BALBc Mice with Sepsis. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043533
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043533
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر