Association of Myeloid Cells of Triggering Receptor-1 with Left Ventricular Systolic Dysfunction in BALBc Mice with Sepsis
Joint Authors
Yao, Huaguo
Deng, Liehua
Zhou, Gaosheng
Ye, Lijun
Zhang, Liang
Zhang, Liangqing
Zhang, Yuanli
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To investigate the correlation between TREM-1 and LPS-induced left ventricular systolic dysfunction in BALB/c mice.
Methods.
Male BALB/c mice were randomly divided into 3 groups: LPS, LPS/TREM-1, and control groups which were injected intraperitoneally with 25 mg/kg LPS, 5 μg TREM-1mAb 1 h after LPS challenge, and sterilized normal saline, respectively.
Left ventricular systolic function was monitored by echocardiography at 6 h, 12 h, and 24 h.
Meanwhile, TNF-α, IL-1β, and sTREM-1 in serum and myocardium were determined by ELISA or real-time PCR; at last left ventricles were taken for light microscopy examination.
Results.
FS and EF in LPS/mAbTREM-1 group, significantly declined compared with LPS and control group at 12 h, were accompanied with a markedly increase in serum IL-1β (at 6 h) and sTREM-1 (at 12 h and 24 h) expression.
Myocardium TNF-α (at 6 h and 24 h) and sTREM-1 (at 6 h) were significantly higher in LPS/mAbTrem-1-treated mice than in time-matched LPS-treated mice; meanwhile myocardium TNF-α mRNA were markedly increased in comparison with LPS-treated or saline-treated mice at 24 h.
Besides, mAbTREM-1 aggravated LPS-induced myocardial damage was observed.
Conclusions.
Our results suggest that TREM-1 is significantly associated with LPS-induced left ventricular systolic dysfunction in BALB/c mice.
American Psychological Association (APA)
Zhou, Gaosheng& Ye, Lijun& Zhang, Liang& Zhang, Liangqing& Zhang, Yuanli& Deng, Liehua…[et al.]. 2014. Association of Myeloid Cells of Triggering Receptor-1 with Left Ventricular Systolic Dysfunction in BALBc Mice with Sepsis. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043533
Modern Language Association (MLA)
Zhou, Gaosheng…[et al.]. Association of Myeloid Cells of Triggering Receptor-1 with Left Ventricular Systolic Dysfunction in BALBc Mice with Sepsis. Mediators of Inflammation No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1043533
American Medical Association (AMA)
Zhou, Gaosheng& Ye, Lijun& Zhang, Liang& Zhang, Liangqing& Zhang, Yuanli& Deng, Liehua…[et al.]. Association of Myeloid Cells of Triggering Receptor-1 with Left Ventricular Systolic Dysfunction in BALBc Mice with Sepsis. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043533
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043533