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Hesperidin Inhibits Inflammatory Response Induced by Aeromonas hydrophila Infection and Alters CD4 +CD8 + T Cell Ratio
المؤلفون المشاركون
Alsulaimani, Adnan Amin
Abuelsaad, Abdelaziz S. A.
Allam, Gamal
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-06
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Aeromonas hydrophila is an opportunistic bacterial pathogen that is associated with a number of human diseases.
Hesperidin (HES) has been reported to exert antioxidant and anti-inflammatory activities.
Objectives.
The aim of this study was to investigate the potential effect of HES treatment on inflammatory response induced by A.
hydrophila infection in murine.
Methods.
A.
hydrophila-infected mice were treated with HES at 250 mg/kg b.wt./week for 4 consecutive weeks.
Phagocytosis, reactive oxygen species production, CD4+/CD8+ T cell ratio, and CD14 expression on intestinal infiltrating monocytes were evaluated.
The expression of E-selectin and intercellular adhesion molecule 1 on stimulated HUVECs and RAW macrophage was evaluated.
Results.
Percentage of CD4+ T cells in the intestinal tissues of infected treated mice was highly significantly increased; however, phagocytic index, ROS production, CD8+ T cells percentage, and CD14 expression on monocytes were significantly reduced.
On the other hand, HES significantly inhibited A-LPS- and A-ECP-induced E-selectin and ICAM-1 expression on HUVECs and ICAM-1 expression on RAW macrophage.
Conclusion.
Present data indicated that HES has a potential role in the suppression of inflammatory response induced by A.
hydrophila toxins through downmodulation of ROS production and CD14 and adhesion molecules expression, as well as increase of CD4+/CD8+ cell ratio.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abuelsaad, Abdelaziz S. A.& Allam, Gamal& Alsulaimani, Adnan Amin. 2014. Hesperidin Inhibits Inflammatory Response Induced by Aeromonas hydrophila Infection and Alters CD4 +CD8 + T Cell Ratio. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043535
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abuelsaad, Abdelaziz S. A.…[et al.]. Hesperidin Inhibits Inflammatory Response Induced by Aeromonas hydrophila Infection and Alters CD4 +CD8 + T Cell Ratio. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043535
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abuelsaad, Abdelaziz S. A.& Allam, Gamal& Alsulaimani, Adnan Amin. Hesperidin Inhibits Inflammatory Response Induced by Aeromonas hydrophila Infection and Alters CD4 +CD8 + T Cell Ratio. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043535
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043535
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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