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Proinflammatory Cytokines and C-Reactive Protein in Uveitis Associated with Behçet’s Disease
المؤلفون المشاركون
Mesquida, Marina
Molins, Blanca
Llorenç, Victor
Sainz de la Maza, Maite
Hernandez, María Victoria
Espinosa, Gerard
Adán, Alfredo
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The aim of the present study was to determine the serum cytokine profile and levels of high sensitivity C-reactive protein (hsCRP) in patients with uveitis associated with Behçet’s disease (BD) and to compare them with those obtained from healthy control subjects.
We determined the serum concentration of interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-12p70, IL-17A, tumor necrosis factor-α (TNF-α), and hsCRP in 13 patients with active uveitis associated to BD, 24 inactive BD patients, and 20 controls.
In a subgroup of 10 active patients, a second serum sample was obtained when the disease was inactive.
Cytokine profiles and hsCRP levels were correlated with disease activity, severity, complications, and visual outcome.
Levels of IFN-γ and TNF-α were significantly increased in patients with active uveitis associated to BD compared to controls (P<0.05).
IFN-γ, TNF-α, and hsCRP were significantly higher during active uveitis associated to BD compared to inactive disease (P<0.05).
Furthermore, IL-17A was significantly increased in patients with active BD without pharmacological treatment compared to controls (P<0.05).
No significant correlations were found with specific cytokine profiles and disease severity, visual outcome, or complications.
In summary, increased serum levels of IFN-γ, TNF-α, IL-17A, and hsCRP were associated with active uveitis associated with BD and might serve as markers of disease activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mesquida, Marina& Molins, Blanca& Llorenç, Victor& Sainz de la Maza, Maite& Hernandez, María Victoria& Espinosa, Gerard…[et al.]. 2014. Proinflammatory Cytokines and C-Reactive Protein in Uveitis Associated with Behçet’s Disease. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043536
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mesquida, Marina…[et al.]. Proinflammatory Cytokines and C-Reactive Protein in Uveitis Associated with Behçet’s Disease. Mediators of Inflammation No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1043536
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mesquida, Marina& Molins, Blanca& Llorenç, Victor& Sainz de la Maza, Maite& Hernandez, María Victoria& Espinosa, Gerard…[et al.]. Proinflammatory Cytokines and C-Reactive Protein in Uveitis Associated with Behçet’s Disease. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043536
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043536
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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