Proinflammatory Cytokines and C-Reactive Protein in Uveitis Associated with Behçet’s Disease
Joint Authors
Mesquida, Marina
Molins, Blanca
Llorenç, Victor
Sainz de la Maza, Maite
Hernandez, María Victoria
Espinosa, Gerard
Adán, Alfredo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of the present study was to determine the serum cytokine profile and levels of high sensitivity C-reactive protein (hsCRP) in patients with uveitis associated with Behçet’s disease (BD) and to compare them with those obtained from healthy control subjects.
We determined the serum concentration of interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-12p70, IL-17A, tumor necrosis factor-α (TNF-α), and hsCRP in 13 patients with active uveitis associated to BD, 24 inactive BD patients, and 20 controls.
In a subgroup of 10 active patients, a second serum sample was obtained when the disease was inactive.
Cytokine profiles and hsCRP levels were correlated with disease activity, severity, complications, and visual outcome.
Levels of IFN-γ and TNF-α were significantly increased in patients with active uveitis associated to BD compared to controls (P<0.05).
IFN-γ, TNF-α, and hsCRP were significantly higher during active uveitis associated to BD compared to inactive disease (P<0.05).
Furthermore, IL-17A was significantly increased in patients with active BD without pharmacological treatment compared to controls (P<0.05).
No significant correlations were found with specific cytokine profiles and disease severity, visual outcome, or complications.
In summary, increased serum levels of IFN-γ, TNF-α, IL-17A, and hsCRP were associated with active uveitis associated with BD and might serve as markers of disease activity.
American Psychological Association (APA)
Mesquida, Marina& Molins, Blanca& Llorenç, Victor& Sainz de la Maza, Maite& Hernandez, María Victoria& Espinosa, Gerard…[et al.]. 2014. Proinflammatory Cytokines and C-Reactive Protein in Uveitis Associated with Behçet’s Disease. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043536
Modern Language Association (MLA)
Mesquida, Marina…[et al.]. Proinflammatory Cytokines and C-Reactive Protein in Uveitis Associated with Behçet’s Disease. Mediators of Inflammation No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1043536
American Medical Association (AMA)
Mesquida, Marina& Molins, Blanca& Llorenç, Victor& Sainz de la Maza, Maite& Hernandez, María Victoria& Espinosa, Gerard…[et al.]. Proinflammatory Cytokines and C-Reactive Protein in Uveitis Associated with Behçet’s Disease. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043536
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043536