Dendritic Cells from Aged Subjects Display Enhanced Inflammatory Responses to Chlamydophila pneumoniae
المؤلفون المشاركون
Agrawal, Anshu
Prakash, Sangeetha
Agrawal, Sudhanshu
Ma, Dandan
Gupta, Sudhir
Peterson, Ellena M.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-09-01
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Chlamydophila pneumoniae (CPn) is a common respiratory pathogen that causes a chronic and persistent airway infection.
The elderly display an increased susceptibility and severity to this infection.
However, the underlying mechanisms are not well understood.
Dendritic cells (DCs) are the initiators and regulators of immune responses.
Therefore, we investigated the role of DCs in the age-associated increased CPn infection in vitro in humans.
Though the expression of activation markers was comparable between the two age groups, DCs from aged subjects secreted enhanced levels of proinflammatory mediators such as TNF- α and CXCL-10 in response to CPn.
In contrast, the secretion of IL-10 and innate interferons, IFN- α and IFN- λ , was severely impaired in DCs from aged donors.
The increased activation of DCs from aged subjects to CPn also resulted in enhanced proliferation of CD4 and CD8 T cells in a DC-T coculture.
Furthermore, T cells primed with CPn-stimulated DCs from aged subjects secreted increased levels of IFN- γ and reduced levels of IL-10 compared to DCs obtained from young subjects.
In summary, DCs from the elderly displayed enhanced inflammatory response to CPn which may result in airway remodeling and increase the susceptibility of the elderly to respiratory diseases such as asthma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Prakash, Sangeetha& Agrawal, Sudhanshu& Ma, Dandan& Gupta, Sudhir& Peterson, Ellena M.& Agrawal, Anshu. 2014. Dendritic Cells from Aged Subjects Display Enhanced Inflammatory Responses to Chlamydophila pneumoniae. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043560
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Prakash, Sangeetha…[et al.]. Dendritic Cells from Aged Subjects Display Enhanced Inflammatory Responses to Chlamydophila pneumoniae. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043560
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Prakash, Sangeetha& Agrawal, Sudhanshu& Ma, Dandan& Gupta, Sudhir& Peterson, Ellena M.& Agrawal, Anshu. Dendritic Cells from Aged Subjects Display Enhanced Inflammatory Responses to Chlamydophila pneumoniae. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043560
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043560
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر