Dendritic Cells from Aged Subjects Display Enhanced Inflammatory Responses to Chlamydophila pneumoniae
Joint Authors
Agrawal, Anshu
Prakash, Sangeetha
Agrawal, Sudhanshu
Ma, Dandan
Gupta, Sudhir
Peterson, Ellena M.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Chlamydophila pneumoniae (CPn) is a common respiratory pathogen that causes a chronic and persistent airway infection.
The elderly display an increased susceptibility and severity to this infection.
However, the underlying mechanisms are not well understood.
Dendritic cells (DCs) are the initiators and regulators of immune responses.
Therefore, we investigated the role of DCs in the age-associated increased CPn infection in vitro in humans.
Though the expression of activation markers was comparable between the two age groups, DCs from aged subjects secreted enhanced levels of proinflammatory mediators such as TNF- α and CXCL-10 in response to CPn.
In contrast, the secretion of IL-10 and innate interferons, IFN- α and IFN- λ , was severely impaired in DCs from aged donors.
The increased activation of DCs from aged subjects to CPn also resulted in enhanced proliferation of CD4 and CD8 T cells in a DC-T coculture.
Furthermore, T cells primed with CPn-stimulated DCs from aged subjects secreted increased levels of IFN- γ and reduced levels of IL-10 compared to DCs obtained from young subjects.
In summary, DCs from the elderly displayed enhanced inflammatory response to CPn which may result in airway remodeling and increase the susceptibility of the elderly to respiratory diseases such as asthma.
American Psychological Association (APA)
Prakash, Sangeetha& Agrawal, Sudhanshu& Ma, Dandan& Gupta, Sudhir& Peterson, Ellena M.& Agrawal, Anshu. 2014. Dendritic Cells from Aged Subjects Display Enhanced Inflammatory Responses to Chlamydophila pneumoniae. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043560
Modern Language Association (MLA)
Prakash, Sangeetha…[et al.]. Dendritic Cells from Aged Subjects Display Enhanced Inflammatory Responses to Chlamydophila pneumoniae. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043560
American Medical Association (AMA)
Prakash, Sangeetha& Agrawal, Sudhanshu& Ma, Dandan& Gupta, Sudhir& Peterson, Ellena M.& Agrawal, Anshu. Dendritic Cells from Aged Subjects Display Enhanced Inflammatory Responses to Chlamydophila pneumoniae. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043560
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043560