Unraveling the Complex Relationship Triad between Lipids, Obesity, and Inflammation
المؤلفون المشاركون
Azhar, Esam
Damanhouri, Ghazi
Qadri, Ishtiaq
Khan, Shahida A.
Ali, Ashraf
Khan, Sarah A.
Zahran, Solafa A.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-28
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Obesity today stands at the intersection between inflammation and metabolic disorders causing an aberration of immune activity, and resulting in increased risk for diabetes, atherosclerosis, fatty liver, and pulmonary inflammation to name a few.
Increases in mortality and morbidity in obesity related inflammation have initiated studies to explore different lipid mediated molecular pathways of attempting resolution that uncover newer therapeutic opportunities of anti-inflammatory components.
Majorly the thromboxanes, prostaglandins, leukotrienes, lipoxins, and so forth form the group of lipid mediators influencing inflammation.
Of special mention are the omega-6 and omega-3 fatty acids that regulate inflammatory mediators of interest in hepatocytes and adipocytes via the cyclooxygenase and lipoxygenase pathways.
They also exhibit profound effects on eicosanoid production.
The inflammatory cyclooxygenase pathway arising from arachidonic acid is a critical step in the progression of inflammatory responses.
New oxygenated products of omega-3 metabolism, namely, resolvins and protectins, behave as endogenous mediators exhibiting powerful anti-inflammatory and immune-regulatory actions via the peroxisome proliferator-activated receptors (PPARs) and G protein coupled receptors (GPCRs).
In this review we attempt to discuss the complex pathways and links between obesity and inflammation particularly in relation to different lipid mediators.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khan, Shahida A.& Ali, Ashraf& Khan, Sarah A.& Zahran, Solafa A.& Damanhouri, Ghazi& Azhar, Esam…[et al.]. 2014. Unraveling the Complex Relationship Triad between Lipids, Obesity, and Inflammation. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1043609
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khan, Shahida A.…[et al.]. Unraveling the Complex Relationship Triad between Lipids, Obesity, and Inflammation. Mediators of Inflammation No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-1043609
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khan, Shahida A.& Ali, Ashraf& Khan, Sarah A.& Zahran, Solafa A.& Damanhouri, Ghazi& Azhar, Esam…[et al.]. Unraveling the Complex Relationship Triad between Lipids, Obesity, and Inflammation. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1043609
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043609
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر