Unraveling the Complex Relationship Triad between Lipids, Obesity, and Inflammation
Joint Authors
Azhar, Esam
Damanhouri, Ghazi
Qadri, Ishtiaq
Khan, Shahida A.
Ali, Ashraf
Khan, Sarah A.
Zahran, Solafa A.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-28
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Obesity today stands at the intersection between inflammation and metabolic disorders causing an aberration of immune activity, and resulting in increased risk for diabetes, atherosclerosis, fatty liver, and pulmonary inflammation to name a few.
Increases in mortality and morbidity in obesity related inflammation have initiated studies to explore different lipid mediated molecular pathways of attempting resolution that uncover newer therapeutic opportunities of anti-inflammatory components.
Majorly the thromboxanes, prostaglandins, leukotrienes, lipoxins, and so forth form the group of lipid mediators influencing inflammation.
Of special mention are the omega-6 and omega-3 fatty acids that regulate inflammatory mediators of interest in hepatocytes and adipocytes via the cyclooxygenase and lipoxygenase pathways.
They also exhibit profound effects on eicosanoid production.
The inflammatory cyclooxygenase pathway arising from arachidonic acid is a critical step in the progression of inflammatory responses.
New oxygenated products of omega-3 metabolism, namely, resolvins and protectins, behave as endogenous mediators exhibiting powerful anti-inflammatory and immune-regulatory actions via the peroxisome proliferator-activated receptors (PPARs) and G protein coupled receptors (GPCRs).
In this review we attempt to discuss the complex pathways and links between obesity and inflammation particularly in relation to different lipid mediators.
American Psychological Association (APA)
Khan, Shahida A.& Ali, Ashraf& Khan, Sarah A.& Zahran, Solafa A.& Damanhouri, Ghazi& Azhar, Esam…[et al.]. 2014. Unraveling the Complex Relationship Triad between Lipids, Obesity, and Inflammation. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1043609
Modern Language Association (MLA)
Khan, Shahida A.…[et al.]. Unraveling the Complex Relationship Triad between Lipids, Obesity, and Inflammation. Mediators of Inflammation No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-1043609
American Medical Association (AMA)
Khan, Shahida A.& Ali, Ashraf& Khan, Sarah A.& Zahran, Solafa A.& Damanhouri, Ghazi& Azhar, Esam…[et al.]. Unraveling the Complex Relationship Triad between Lipids, Obesity, and Inflammation. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1043609
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043609