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Lycopene Modulates THP1 and Caco2 Cells Inflammatory State through Transcriptional and Nontranscriptional Processes
المؤلفون المشاركون
Makon-Sébastien, Njock
Francis, Fouchier
Eric, Seree
Henri, Villard Pierre
François, Landrier Jean
Laurent, Pechere
Yves, Barra
Serge, Champion
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-07
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
We revisited the action of a carotenoid, the lycopene, on the expression of proinflammatory genes, reactive oxygen species (ROS) production, and metalloprotease (MMP9) activity.
THP1 and Caco2 cell lines were used as in vitro models for the two main cell types found in intestine tissue, that is, monocytes and epithelial cells.
Proinflammatory condition was induced using either phorbol ester acetate (PMA), lipopolysaccharide (LPS) or tumor necrosis factor (TNF).
In THP1 cells, short term pretreatment (2 h) with a low concentration (2 μM) of lycopene reinforce proinflammatory gene expression.
The extent of the effect of lycopene is dependent on the proinflammtory stimulus (PMA, LPS or TNF) used.
Lycopene enhanced MMP9 secretion via a c-AMP-dependent process, and reduced ROS production at higher concentrations than 2 μM.
Cell culture media, conditioned by PMA-treated monocytes and then transferred on CaCo-2 epithelial cells, induced a proinflammatory state in these cells.
The extent of this inflammatory effect was reduced when cells has been pretreated (12 h) with lycopene.
At low concentration (2 μM or less), lycopene appeared to promote an inflammatory state not correlated with ROS modulation.
At higher concentration (5 μM–20 μM), an anti-inflammatory effect takes place as a decrease of ROS production was detected.
So, both concentration and time have to be considered in order to define the exact issue of the effect of carotenoids present in meals.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Makon-Sébastien, Njock& Francis, Fouchier& Eric, Seree& Henri, Villard Pierre& François, Landrier Jean& Laurent, Pechere…[et al.]. 2014. Lycopene Modulates THP1 and Caco2 Cells Inflammatory State through Transcriptional and Nontranscriptional Processes. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043622
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Makon-Sébastien, Njock…[et al.]. Lycopene Modulates THP1 and Caco2 Cells Inflammatory State through Transcriptional and Nontranscriptional Processes. Mediators of Inflammation No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1043622
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Makon-Sébastien, Njock& Francis, Fouchier& Eric, Seree& Henri, Villard Pierre& François, Landrier Jean& Laurent, Pechere…[et al.]. Lycopene Modulates THP1 and Caco2 Cells Inflammatory State through Transcriptional and Nontranscriptional Processes. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043622
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043622
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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