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Elevated OPN, IP-10, and Neutrophilia in Loop-Mediated Isothermal Amplification Confirmed Tuberculosis Patients
المؤلفون المشاركون
Suzuki, Yasuhiko
Telan, Elizabeth Freda O.
Shiratori, Beata
Nakajima, Chie
Chagan-Yasutan, Haorile
Niki, Toshiro
Ashino, Yugo
Hattori, Toshio
Leano, Prisca Susan A.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-10-14
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Tuberculosis (TB) is the second most common cause of death from infectious diseases and results in high socioeconomic losses to many countries.
Proper diagnosis is the first step in TB eradication.
To develop a rapid, simple, and accurate diagnostic TB test and to characterize the prevalence of Mycobacterium tuberculosis (MTB) genotypes and immune profiles of TB patients, a total of 37 TB patients and 30 healthy control (HC) from Metro Manila were enrolled.
Loop-mediated isothermal amplification (LAMP) reliably detected MTB infection.
Manila genotype was identified by spoligotyping method in all TB patients.
Osteopontin (OPN), interferon- γ -induced protein 10 kDa (IP-10), and neutrophil counts were found to reflect the acute stage of MTB infection.
The sensitivity and specificity were 94.6% and 93.3%, respectively, for both OPN and IP-10, and they were 83.8% and 78.6%, respectively, for neutrophils.
The combination of OPN, IP-10, neutrophil count, IL-6, IL-8, TNF- α , MCP-1, platelets, galectin-9, and leukocyte count correctly identifies all the HC and 96.3% of TB patients.
LAMP method may serve as a rapid, supportive method in addition to time-consuming culture methods.
OPN, IP-10, and neutrophil counts are useful in detecting MTB infection and may have utility in monitoring the course of the disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shiratori, Beata& Leano, Prisca Susan A.& Nakajima, Chie& Chagan-Yasutan, Haorile& Niki, Toshiro& Ashino, Yugo…[et al.]. 2014. Elevated OPN, IP-10, and Neutrophilia in Loop-Mediated Isothermal Amplification Confirmed Tuberculosis Patients. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043627
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shiratori, Beata…[et al.]. Elevated OPN, IP-10, and Neutrophilia in Loop-Mediated Isothermal Amplification Confirmed Tuberculosis Patients. Mediators of Inflammation No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1043627
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shiratori, Beata& Leano, Prisca Susan A.& Nakajima, Chie& Chagan-Yasutan, Haorile& Niki, Toshiro& Ashino, Yugo…[et al.]. Elevated OPN, IP-10, and Neutrophilia in Loop-Mediated Isothermal Amplification Confirmed Tuberculosis Patients. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043627
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043627
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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