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Involvement of Different CD4+ T Cell Subsets Producing Granzyme B in the Immune Response to Leishmania major Antigens
المؤلفون المشاركون
Naouar, Ikbel
Boussoffara, Thouraya
Ben Ahmed, Melika
Belhaj Hmida, Nabil
Gharbi, Adel
Gritli, Sami
Ben Salah, Afif
Louzir, Hechmi
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-01
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The nature of effector cells and the potential immunogenicity of Leishmania major excreted/secreted proteins (LmES) were evaluated using peripheral blood mononuclear cells (PBMCs) from healed zoonotic cutaneous leishmaniasis individuals (HZCL) and healthy controls (HC).
First, we found that PBMCs from HZCL individuals proliferate and produce high levels of IFN-γ and granzyme B (GrB), used as a marker of activated cytotoxic T cells, in response to the parasite antigens.
IFN-γ is produced by CD4+ T cells, but unexpectedly GrB is also produced by CD4+ T cells in response to stimulation with LmES, which were found to be as effective as soluble Leishmania antigens to induce proliferation and cytokine production by PBMCs from immune individuals.
To address the question of regulatory T cell (Tregs) involvement, the frequency of circulating Tregs was assessed and found to be higher in HZCL individuals compared to that of HC.
Furthermore, both CD4+CD25+ and CD4+CD25− T cells, purified from HZCL individuals, produced IFN-γ and GrB when stimulated with LmES.
Additional experiments showed that CD 4 + CD 25 + CD 127 dim/ - Tregs were involved in GrB production.
Collectively, our data indicate that LmES are immunogenic in humans and emphasize the involvement of CD4+ T cells including activated and regulatory T cells in the immune response against parasite antigens.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Naouar, Ikbel& Boussoffara, Thouraya& Ben Ahmed, Melika& Belhaj Hmida, Nabil& Gharbi, Adel& Gritli, Sami…[et al.]. 2014. Involvement of Different CD4+ T Cell Subsets Producing Granzyme B in the Immune Response to Leishmania major Antigens. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043695
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Naouar, Ikbel…[et al.]. Involvement of Different CD4+ T Cell Subsets Producing Granzyme B in the Immune Response to Leishmania major Antigens. Mediators of Inflammation No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1043695
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Naouar, Ikbel& Boussoffara, Thouraya& Ben Ahmed, Melika& Belhaj Hmida, Nabil& Gharbi, Adel& Gritli, Sami…[et al.]. Involvement of Different CD4+ T Cell Subsets Producing Granzyme B in the Immune Response to Leishmania major Antigens. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043695
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043695
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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