Selective Vitamin D Receptor Activation as Anti-Inflammatory Target in Chronic Kidney Disease
المؤلفون المشاركون
Donate-Correa, J.
Domínguez-Pimentel, V.
Méndez-Pérez, M. L.
Muros-de-Fuentes, M.
Mora-Fernández, C.
Martín-Núñez, E.
Cazaña-Pérez, V.
Navarro-González, J. F.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-06
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Paricalcitol, a selective vitamin D receptor (VDR) activator used for treatment of secondary hyperparathyroidism in chronic kidney disease (CKD), has been associated with survival advantages, suggesting that this drug, beyond its ability to suppress parathyroid hormone, may have additional beneficial actions.
In this prospective, nonrandomised, open-label, proof-of-concept study, we evaluated the hypothesis that selective vitamin D receptor activation with paricalcitol is an effective target to modulate inflammation in CKD patients.
Eight patients with an estimated glomerular filtration rate between 15 and 44 mL/min/1.73 m2 and an intact parathyroid hormone (PTH) level higher than 110 pg/mL received oral paricalcitol (1 μg/48 hours) as therapy for secondary hyperparathyroidism.
Nine patients matched by age, sex, and stage of CKD, but a PTH level <110 pg/mL, were enrolled as a control group.
Our results show that five months of paricalcitol administration were associated with a reduction in serum concentrations of hs-CRP (13.9%, P < 0.01 ), TNF-α (11.9%, P = 0.01 ), and IL-6 (7%, P < 0.05 ), with a nonsignificant increase of IL-10 by 16%.
In addition, mRNA expression levels of the TNFα and IL-6 genes in peripheral blood mononuclear cells decreased significantly by 30.8% ( P = 0.01 ) and 35.4% ( P = 0.01 ), respectively.
In conclusion, selective VDR activation is an effective target to modulate inflammation in CKD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Donate-Correa, J.& Domínguez-Pimentel, V.& Méndez-Pérez, M. L.& Muros-de-Fuentes, M.& Mora-Fernández, C.& Martín-Núñez, E.…[et al.]. 2014. Selective Vitamin D Receptor Activation as Anti-Inflammatory Target in Chronic Kidney Disease. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1043706
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Donate-Correa, J.…[et al.]. Selective Vitamin D Receptor Activation as Anti-Inflammatory Target in Chronic Kidney Disease. Mediators of Inflammation No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1043706
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Donate-Correa, J.& Domínguez-Pimentel, V.& Méndez-Pérez, M. L.& Muros-de-Fuentes, M.& Mora-Fernández, C.& Martín-Núñez, E.…[et al.]. Selective Vitamin D Receptor Activation as Anti-Inflammatory Target in Chronic Kidney Disease. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1043706
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043706
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر