Selective Vitamin D Receptor Activation as Anti-Inflammatory Target in Chronic Kidney Disease
Joint Authors
Donate-Correa, J.
Domínguez-Pimentel, V.
Méndez-Pérez, M. L.
Muros-de-Fuentes, M.
Mora-Fernández, C.
Martín-Núñez, E.
Cazaña-Pérez, V.
Navarro-González, J. F.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Paricalcitol, a selective vitamin D receptor (VDR) activator used for treatment of secondary hyperparathyroidism in chronic kidney disease (CKD), has been associated with survival advantages, suggesting that this drug, beyond its ability to suppress parathyroid hormone, may have additional beneficial actions.
In this prospective, nonrandomised, open-label, proof-of-concept study, we evaluated the hypothesis that selective vitamin D receptor activation with paricalcitol is an effective target to modulate inflammation in CKD patients.
Eight patients with an estimated glomerular filtration rate between 15 and 44 mL/min/1.73 m2 and an intact parathyroid hormone (PTH) level higher than 110 pg/mL received oral paricalcitol (1 μg/48 hours) as therapy for secondary hyperparathyroidism.
Nine patients matched by age, sex, and stage of CKD, but a PTH level <110 pg/mL, were enrolled as a control group.
Our results show that five months of paricalcitol administration were associated with a reduction in serum concentrations of hs-CRP (13.9%, P < 0.01 ), TNF-α (11.9%, P = 0.01 ), and IL-6 (7%, P < 0.05 ), with a nonsignificant increase of IL-10 by 16%.
In addition, mRNA expression levels of the TNFα and IL-6 genes in peripheral blood mononuclear cells decreased significantly by 30.8% ( P = 0.01 ) and 35.4% ( P = 0.01 ), respectively.
In conclusion, selective VDR activation is an effective target to modulate inflammation in CKD.
American Psychological Association (APA)
Donate-Correa, J.& Domínguez-Pimentel, V.& Méndez-Pérez, M. L.& Muros-de-Fuentes, M.& Mora-Fernández, C.& Martín-Núñez, E.…[et al.]. 2014. Selective Vitamin D Receptor Activation as Anti-Inflammatory Target in Chronic Kidney Disease. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1043706
Modern Language Association (MLA)
Donate-Correa, J.…[et al.]. Selective Vitamin D Receptor Activation as Anti-Inflammatory Target in Chronic Kidney Disease. Mediators of Inflammation No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1043706
American Medical Association (AMA)
Donate-Correa, J.& Domínguez-Pimentel, V.& Méndez-Pérez, M. L.& Muros-de-Fuentes, M.& Mora-Fernández, C.& Martín-Núñez, E.…[et al.]. Selective Vitamin D Receptor Activation as Anti-Inflammatory Target in Chronic Kidney Disease. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1043706
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043706